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Cat. No.: HY-124941

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7-Deacetylgedunin

7-Deacetylgedunin is an activator of Keap1/Nrf2/HO-1. 7-Deacetylgedunin alleviates mice mortality induced by LPS. 7-Deacetylgedunin inhibits Keap1 expression and suppresses macrophage proliferation. 7-Deacetylgedunin suppresses inflammation in vivo and in vitro.

For research use only. We do not sell to patients.

CAS No.: 10314-90-6
Formula: C₂₆H₃₂O₆
Molecular Weight:440.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

7-Deacetylgedunin Chemical Structure

CAS No.: 10314-90-6

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Protocols (3)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>20 μM Compound: 17	Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
AZ-521 cell line	IC₅₀	16.9 μM Compound: 17	Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human AZ-521 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
HepG2	IC₅₀	10.26 μM Compound: 12	Cytotoxicity against human HepG2 cells after 3 days by MTT assay Cytotoxicity against human HepG2 cells after 3 days by MTT assay	[PMID: 19908853]
HL-60	IC₅₀	>20 μM Compound: 17	Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human HL60 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
Huh-7	CC₅₀	105 μM Compound: 9	Cytotoxicity against human HuH7 cells after 72 hrs by MTS assay Cytotoxicity against human HuH7 cells after 72 hrs by MTS assay	[PMID: 25330401]
Huh-7	EC₅₀	12.5 μM Compound: 9	Antiviral activity against dengue virus 2 infected in human HuH7 cells after 72 hrs by Western blot and ECL detection based assay Antiviral activity against dengue virus 2 infected in human HuH7 cells after 72 hrs by Western blot and ECL detection based assay	[PMID: 25330401]
L6	IC₅₀	13.3 μg/mL Compound: 4	Cytotoxicity against rat L6 cells Cytotoxicity against rat L6 cells	[PMID: 17253841]
L6	IC₅₀	5.2 μg/mL Compound: 4	Antiprotozoal activity against Trypanosoma cruzi Tulahuen C2C4 trypomastigotes in L6 cells Antiprotozoal activity against Trypanosoma cruzi Tulahuen C2C4 trypomastigotes in L6 cells	[PMID: 17253841]
MCF7	IC₅₀	28.96 μM Compound: 2	Antiproliferative activity against human MCF7 cells after 72 hrs Antiproliferative activity against human MCF7 cells after 72 hrs	[PMID: 18816111]
P388	IC₅₀	4.5 μg/mL Compound: 6	Cytotoxicity against mouse P388 cells Cytotoxicity against mouse P388 cells	[PMID: 16989525]
RAW264.7	IC₅₀	<10 μM Compound: 7	Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite level after 24 hrs by Griess method Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assessed as nitrite level after 24 hrs by Griess method	[PMID: 21733687]
RAW264.7	IC₅₀	37.58 μM Compound: 7	Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay Cytotoxicity against mouse RAW264.7 cells after 24 hrs by MTT assay	[PMID: 21733687]
RAW264.7	IC₅₀	9.191 μM Compound: B; DAG	Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay Antiinflammatory activity in mouse RAW264.7 assessed as inhibition of LPS-induced NO production incubated for 1 hrs followed by LPS stimulation for 18 hrs by Griess reagent based assay	[PMID: 35427124]
SK-BR-3	IC₅₀	12 μM Compound: 17	Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay Cytotoxicity against human SK-BR-3 cells assessed as cell viability after 48 hrs by MTT assay	[PMID: 21381696]
SK-BR-3	IC₅₀	21.09 μM Compound: 2	Antiproliferative activity against human SKBr3 cells after 72 hrs Antiproliferative activity against human SKBr3 cells after 72 hrs	[PMID: 18816111]

Chemical Information

CAS No. 10314-90-6
Molecular Weight 440.53
Formula C₂₆H₃₂O₆
SMILES

C[C@]12[C@]34[C@]([C@H](C5=COC=C5)OC([C@@]3([H])O4)=O)(CC[C@]1([H])[C@@]6([C@@](C(C)(C(C=C6)=O)C)([H])C[C@H]2O)C)C
Structure Classification
- Others
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Molecular Biology Signal Pathway Related Cell Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Research Protocol for Inflammation-related Diseases
The NLRP3 inflammasome is a cytosolic innate immune signaling platform that integrates priming signals and danger-signal activation to promote caspase-1 activation, maturation of IL-1β and IL-18, and gasdermin D-mediated pyroptotic cell death. The core experimental logic is to determine whether inflammatory disease phenotypes are driven by increased NLRP3 expression, ASC-containing inflammasome assembly, caspase-1 cleavage, GSDMD cleavage, and extracellular release of IL-1β/IL-18 rather than by nonspecific cell injury alone. The pathway is strongly linked to inflammation-related disease phenotypes because monosodium urate crystals activate NALP3/NLRP3 inflammasome signaling in gout-like crystal inflammation, cholesterol crystals activate NLRP3 inflammasomes in atherogenesis models, and DSS-induced intestinal inflammation has been reported to involve NLRP3 inflammasome activity. However, experimental colitis studies also show context-dependent protective effects of NLRP3 inflammasome co
Cell Viability Determination by MTT Colorimetric Assay
The following protocol uses the MTT colorimetric assay as a classic literature-established method for assessing cell viability/metabolic activity in cultured mammalian cells. MTT[3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] is reduced by metabolically active cells to a colored formazan product; the amount of formazan is quantified spectrophotometrically and provides an indirect measure of metabolically active viable cells. Importantly, MTT reduction reflects cellular oxidoreductase/metabolic activity rather than an absolute direct count of living cells, so changes in cellular metabolism can alter the signal independently of cell number.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chen JY, et al. 7-deacetylgedunin suppresses inflammatory responses through activation of Keap1/Nrf2/HO-1 signaling. Oncotarget. 2017 Jul 5;8(33):55051-55063. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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