Pomalidomide-13C5
Pomalidomide-13C5 (CC-4047-13C5) is the 13C-labeled Pomalidomide (HY-10984). Pomalidomide (CC-4047) is an immunomodulatory agent. Pomalidomide downregulates TNF-alpha, IL-1, IL-11, and IL-12, upregulates IL-2, IL-5, and IL-10, and costimulates T cells. Pomalidomide inhibits the proliferation of T regulatory cells by reducing FOXP3/OX-40 expression and IL-2-mediated expansion. Pomalidomide inhibits CDK2/4/6 and p21WAF-1, causing cell cycle arrest. Pomalidomide can be used in research on myelofibrosis-associated anemia, multiple myeloma, and colorectal cancer.
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- CAS. Nr.: 1416575-79-5
- Formel: C813C5H11N3O4
- Molecular Weight:278.21
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biologische Aktivität
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Chemical Information
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- Reinheit & Dokumentation
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Help & FAQs
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Biologische Aktivität
Beschreibung
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IL-1 |
TNF-alpha |
IL-12 |
IL-2 |
IL-5 |
IL-10 |
IL-11 |
FOXP3 |
CDK2 |
OX-40 |
CDK4 |
CDK6 |
Anwendung
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 1416575-79-5
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Unlabeled CAS 19171-19-8
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Molecular Weight 278.21
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Formel C813C5H11N3O4
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SMILES
O=C1N([13CH]2[13C](N[13C]([13CH2][13CH2]2)=O)=O)C(C3=C(N)C=CC=C31)=O
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Synonyms
CC-4047-13C5
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Pomalidomide-13C5 Related Classifications
HY-10984S4 Related Classifications
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Keywords
- Pomalidomide-13C5
- 1416575-79-5
- CC-4047-13C5
- Isotope-Labeled Compounds
- TNF Receptor
- Interleukin Related
- FOXP
- Orexin Receptor (OX Receptor)
- CDK
- Tumor Necrosis Factor Receptor
- TNFR
- IL
- Forkhead Box P Protein
- Hypocretin Receptor
- HCRT Receptor
- Cyclin dependent kinase
- FOXP3
- IL-1
- IL-10
- IL-11
- IL-12
- IL-2
- IL-5
- T cells
- T-regulatory cell
- TNF-alpha
- Inhibitor
- inhibitor
- inhibit