Search Result

Results for "

IL-10

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Interleukin Related (20) Adenosine Deaminase (1) Adenosine Receptor (4) Apoptosis (4) Bacterial (3) Cannabinoid Receptor (3) CDK (2) COX (1) Endogenous Metabolite (4) HDAC (4) IFNAR (3) Leukotriene Receptor (1) MALT1 (3) Neurokinin Receptor (2) NF-κB (1) NO Synthase (1) NOD-like Receptor (NLR) (4) Parasite (1) Phosphodiesterase (PDE) (3) Reactive Oxygen Species (2) Salt-inducible Kinase (SIK) (1) Small Interfering RNA (siRNA) (5) TGF-β Receptor (2) TNF Receptor (12) Toll-like Receptor (TLR) (3)
By Research Areas:	Cancer (10) Cardiovascular Disease (1) Infection (4) Inflammation/Immunology (41) Metabolic Disease (1) Neurological Disease (2)

By Targets:

Interleukin Related (20)

Adenosine Deaminase (1)

Adenosine Receptor (4)

Apoptosis (4)

Bacterial (3)

Cannabinoid Receptor (3)

CDK (2)

COX (1)

Endogenous Metabolite (4)

HDAC (4)

IFNAR (3)

Leukotriene Receptor (1)

MALT1 (3)

Neurokinin Receptor (2)

NF-κB (1)

NO Synthase (1)

NOD-like Receptor (NLR) (4)

Parasite (1)

Phosphodiesterase (PDE) (3)

Reactive Oxygen Species (2)

Salt-inducible Kinase (SIK) (1)

Small Interfering RNA (siRNA) (5)

TGF-β Receptor (2)

TNF Receptor (12)

Toll-like Receptor (TLR) (3)

By Research Areas:

Cancer (10)

Cardiovascular Disease (1)

Infection (4)

Inflammation/Immunology (41)

Metabolic Disease (1)

Neurological Disease (2)

Inhibitors & Agonists

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Antibodies

Targets Recommended: Neprilysin Interleukin Related IRAK Itk Apical Sodium-Dependent Bile Acid Transporter

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-RS06670

IL10 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL10 Human Pre-designed siRNA Set A contains three designed siRNAs for IL10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL10 Human Pre-designed siRNA Set A IL10 Human Pre-designed siRNA Set A

HY-RS06671

Il10 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il10 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il10 Mouse Pre-designed siRNA Set A Il10 Mouse Pre-designed siRNA Set A

HY-RS06672

Il10 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Il10 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il10 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Il10 Rat Pre-designed siRNA Set A Il10 Rat Pre-designed siRNA Set A

HY-RS06673

IL10RA Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL10RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL10RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL10RA Human Pre-designed siRNA Set A IL10RA Human Pre-designed siRNA Set A

HY-RS06674

IL10RB Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
IL10RB Human Pre-designed siRNA Set A contains three designed siRNAs for IL10RB gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

IL10RB Human Pre-designed siRNA Set A IL10RB Human Pre-designed siRNA Set A

HY-P990001

Anti-Mouse IL-10 Antibody

Interleukin Related Inflammation/Immunology

Anti-Mouse IL-10 Antibody is an IgG1 antibody inhibitor against mouse IL-10. Derived from rat.

*Anti-Mouse IL-10* Antibody**	Interleukin Related	Inflammation/Immunology
Anti-Mouse IL-10 Antibody is an IgG1 antibody inhibitor against mouse IL-10. Derived from rat.

HY-147527

CDK8-IN-5	CDK	Inflammation/Immunology
CDK8-IN-5 is a potent CDK8 inhibitor with an IC₅₀ of 72 nM. CDK8-IN-5 shows anti-inflammatory activities with 43% IL-10 enhancement rate. CDK8-IN-5 has the potential for the research of inflammatory bowel disease .

HY-122586

BRD6989	CDK Interleukin Related	Inflammation/Immunology
BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates *IL-10. BRD6989 selectively binds a complex of CDK8 with an IC₅₀* of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes .

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-147506

NOD2 antagonist 1	NOD-like Receptor (NLR)	Inflammation/Immunology
NOD2 antagonist 1 (compound 32) is a potent and selective NOD2 antagonist with an IC₅₀ of 5.23 μM. NOD2 antagonist 1 inhibits Muramyl dipeptide (MDP)-induced IL-8 secretion in THP-1 cells and inhibits MDP-induced IL-6, IL-10, TNF-α release in PBMCs .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-101757

NO-prednisolone NCX-1015	Interleukin Related	Inflammation/Immunology
NO-prednisolone is a nitric oxide (NO)-releasing derivative of Prednisolone. NO-prednisolone potently stimulates *IL-10* production in vivo.

HY-23119

Sodium thiocyanate, GR, 99% Thiocyanate sodium	Interleukin Related Reactive Oxygen Species	Inflammation/Immunology
Sodium thiocyanate reduces plasma levels of the pro-inflammatory cytokine IL-6, and increases the anti-inflammatory cytokine *IL-10* levels. Sodium thiocyanate also significantly reduces of ROS formation .

HY-110133

JTE-607 1 Publications Verification	Interleukin Related	Inflammation/Immunology
JTE-607, a highly selective inflammatory cytokine synthesis inhibitor, protects from endotoxin shock in mice. JTE-607 inhibits inflammatory cytokine production, including TNF-α, IL-1β, IL-6, IL-8 and *IL-10, from LPS-stimulated human PBMCs, with IC₅₀*s of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively . Cleavage and Polyadenylation Specificity Factor 3 (CPSF3) is the target of JTE-607 .

HY-160040

Cobitolimod	Toll-like Receptor (TLR)	Inflammation/Immunology
Cobitolimod is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod suppresses Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .

HY-160040A

Cobitolimod sodium	Toll-like Receptor (TLR)	Inflammation/Immunology
Cobitolimod sodium is a DNA oligonucleotide agonist of TLR-9 with anti-inflammatory activity. Cobitolimod sodium inhibits Th17 cells and induces anti-inflammatory FoxP3 and IL-10 expression, inhibiting the IL-17 signaling pathway .

HY-N0600

Ginsenoside F3	Interleukin Related IFNAR	Inflammation/Immunology
Ginsenoside F3, a component of PPTGs (an minor saponin in the leaves of Panax ginseng), has immunoenhancing activity by regulating production and gene expression of type 1 cytokines (IL-2, IFN-gamma) and type 2 cytokines (IL-4 and IL-10) .

HY-101019

Ossirene 1 Publications Verification AS101
Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor . Ossirene abolishes phosphorylation of STAT3 by inhibiting *IL-10. Ossirene potently inhibits Caspase-1* and is used for the autoimmune diseases and certain malignancies .

HY-143422A

(R)-MALT1-IN-3	MALT1	Cancer
(R)-MALT1-IN-3 (compound 121) is a potent MALT1 protease inhibitor with an IC₅₀ of 20 nM. (R)-MALT1-IN-3 has IC₅₀ of 60 nM, 40 nM for human IL6/IL10 in OCI-LY3 cells, respectively .

HY-143422

MALT1-IN-3	MALT1	Cancer
MALT1-IN-3 (compound 122) is a potent MALT1 protease inhibitor, with an IC₅₀ of 0.06 μM. MALT1-IN-3 has IC₅₀ of 0.14 and 0.13 μM for human IL6/IL10 in OCI-LY3 cells, respectively .

HY-15507

VGX-1027 1 Publications Verification GIT 27	Interleukin Related TNF Receptor	Metabolic Disease Inflammation/Immunology
VGX-1027 is an orally active isoxazole compound that exhibits various immunomodulatory properties. VGX-1027 targets macrophages, reducing the production of the proinflammatory mediators TNF-α, IL-1β, IL-10. VGX-1027 has antidiabetogenic effects by limiting cytokine-mediated immunoinflammatory events .

HY-N6607

Tryptanthrin 2 Publications Verification	Leukotriene Receptor NO Synthase NF-κB COX TNF Receptor Interleukin Related	Inflammation/Immunology Cancer
Tryptanthrin is an indole quinazoline that could be an alkaloid from indigo-bearing plants. Tryptanthrin is a potent and orally active cellular Leukotriene (LT) biosynthesis inhibitor. Tryptanthrin has anticancer activity. Tryptanthrin suppresses the expression levels of NOS1, COX-2, and NF-κB and regulates the expression levels of IL-2, IL-10, and TNF-α .

HY-N0405

Orientin 2 Publications Verification	TNF Receptor Interleukin Related	Neurological Disease Cancer
Orientin is a neuroprotective agentinhibits which has anti-inflammation, anti-oxidative, anti-tumor, and cardio protection properties. Orientin inhibits the levels of IL-6, IL-1β and TNF-α. Orientin increases *IL-10* level. Orientin exhibits neuroprotective effect by inhibits TLR4 and NF-kappa B signaling pathway. Orientin can used in study neuropathic pain .

HY-147105

LRH-1 modulator-1	Others	Inflammation/Immunology
LRH-1 modulator-1 (compound 6N) is a potent LRH-1 (liver receptor homolog-1) modulator/agonist. LRH-1 modulator-1 shows anti-inflammatory effects in intestinal organoids. LRH-1 modulator-1 induces anti-inflammatory cytokine IL-10, and reduces inflammatory cytokine IL-1b and TNFa .

HY-107390A

AX-024 hydrochloride 1 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
AX-024 hydrochloride is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 hydrochloride modulates cell signaling by targeting SH3 domains. AX-024 hydrochloride has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-107390

AX-024 1 Publications Verification	TNF Receptor Interleukin Related IFNAR	Inflammation/Immunology
AX-024 is an orally available, first-in-class inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation with an IC₅₀ ~1 nM. AX-024 modulates cell signaling by targeting SH3 domains. AX-024 has low-acute toxicity and high potency and selectivity, and strongly inhibit the production of IL-6, TNF-α, IFN-γ, *IL-10* and IL-17A.

HY-N7176

Kaempferol 3-O-β-D-glucuronide 2 Publications Verification Kaempferol-3-glucuronide; Kaempferol-3-O-glucuronide	Interleukin Related	Inflammation/Immunology
Kaempferol 3-O-β-D-glucuronide (Kaempferol-3-glucuronide), one conjugated kaempferol metabolite, has anti-inflammatory effect. Kaempferol 3-O-β-D-glucuronide significantly inhibits various pro-inflammatory mediators like IL-1β, NO, PGE2, and LTB4. Kaempferol 3-O-β-D-glucuronide upregulates the secretion of anti-inflammatory cytokine IL-10 .

HY-107909

Theophylline sodium glycinate 1,3-Dimethylxanthine sodium glycinate; Theo-24 sodium glycinate	Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor	Cancer
Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-150232

MALT1-IN-11	MALT1	Inflammation/Immunology Cancer
MALT1-IN-11 (Example 151 in reference Patent) is a MALT1 protease inhibitor (IC₅₀ < 10 nM). MALT1-IN-11 inhibits IL10 secretion with an IC₅₀ of 10-100 nM. MALT1-IN-11 can be used for the research of cancer, autoimmune and inflammatory disorders .

HY-113402A

Gamma-glutamylcysteine TFA γ-Glutamylcysteine TFA	Interleukin Related TNF Receptor Endogenous Metabolite	Inflammation/Immunology
Gamma-glutamylcysteine (γ-Glutamylcysteine) TFA, an intermediate in glutathione (GSH) synthesis, is a dipeptide served as an essential cofactor for the antioxidant enzyme glutathione peroxidase (GPx). Gamma-glutamylcysteine TFA also upregulates the level of the anti-inflammatory cytokine *IL-10* and reduces the levels of the pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β). Gamma-glutamylcysteine TFA attenuates the changes in metalloproteinase activity in oligomeric Aβ40-treated astrocytes .

HY-110353

CU-T12-9 3 Publications Verification	Toll-like Receptor (TLR)	Inflammation/Immunology Cancer
CU-T12-9 is a specific TLR1/2 agonist with EC₅₀ of 52.9 nM in HEK-Blue hTLR2 SEAP assay. CU-T12-9 activates both the innate and the adaptive immune systems. CU-T12-9 selectively activates the TLR1/2 heterodimer, not TLR2/6. CU-T12-9 signals through NF-κB and invokes an elevation of the downstream effectors TNF-α, IL-10, and iNOS .

HY-155520

Antileishmanial agent-19	Parasite	Infection
Antileishmanial agent-19 (Compound F27) is an antileishmanial agent, with a IC₅₀ of 3.39 μM for L. donovani promastigotes. Antileishmanial agent-19 inhibits Leishmania prolyl-tRNA synthetase. Antileishmanial agent-19 inhibits host PI3K/Akt/CREB axis-mediated IL-10 secretion. Antileishmanial agent-19 induces autophagy-mediated apoptosis in L. donovani promastigotes. Antileishmanial agent-19 reduces parasite burden in L.d-infected animals .

HY-149365

SIKs-IN-1	Salt-inducible Kinase (SIK)	Inflammation/Immunology
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model .

HY-N1940

β-Anhydroicaritin 1 Publications Verification
β-Anhydroicaritin is isolated from Boswellia carterii Birdware, has important biological and pharmacological effects, such as antiosteoporosis, estrogen regulation and antitumor properties . β-Anhydroicaritin ameliorates the degradation of periodontal tissue and inhibits the synthesis and secretion of TNF-α and MMP-3 in diabetic rats . β-Anhydroicaritin decreases the overproduction of NO, IL-10, TNF-α, MCP-1 and IL-6 in inperitonitis mice. β-Anhydroicaritin inhibits the elevation of intracellular Ca ²⁺, and markedly decreases iNOS protein expression .

HY-B0809

Theophylline Maximum Cited Publications 6 Publications Verification 1,3-Dimethylxanthine; Theo-24	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite	Cancer
Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809B

Theophylline sodium acetate 1,3-Dimethylxanthine sodium acetate; Theo-24 sodium acetate	Endogenous Metabolite Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor	Cancer
Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809A

Theophylline monohydrate 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate
Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-B0809R

Theophylline (Standard) 1,3-Dimethylxanthine(Standard); Theo-24 (Standard)	Phosphodiesterase (PDE) Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor Endogenous Metabolite	Cancer
Theophylline (Standard) is the analytical standard of Theophylline. This product is intended for research and analytical applications. Theophylline (1,3-Dimethylxanthine) is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) induces apoptosis. Theophylline (1,3-Dimethylxanthine) can be used for asthma and chronic obstructive pulmonary disease (COPD) research .

HY-N0976

1,11b-Dihydro-11b-hydroxymedicarpin 11b-Hydroxy-11b,1-dihydromedicarpin	Interleukin Related	Inflammation/Immunology
1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative . Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways . Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice .

HY-137553

β-Aminoarteether SM934 free base	NOD-like Receptor (NLR)	Inflammation/Immunology
β-Aminoarteether (SM934 free base) is an Artemisinin derivative with orally active. β-Aminoarteether can be used for inflammation and autoimmune disease research, such as lupus diseases .

HY-137553A

β-Aminoarteether maleate SM934	NOD-like Receptor (NLR)	Inflammation/Immunology
β-Aminoarteether maleate (SM934) is an Artemisinin derivative with orally active. β-Aminoarteether maleate can be used for inflammation and autoimmune disease research, such as lupus diseases .

HY-122154

FR234938	Adenosine Deaminase	Inflammation/Immunology
FR234938 is a non-nucleoside adenosine deaminase inhibitor with an IC₅₀ of 17 nM for recombinant human adenosine deaminase enzyme. FR234938 has anti-rheumatic and anti-inflammatory effects .

HY-N7697D

Chitoheptaose heptahydrochloride	Reactive Oxygen Species	Cardiovascular Disease Inflammation/Immunology
Chitoheptaose heptahydrochloride is a chitosan oligosaccharide with antioxidant, anti-inflammatory, antiapoptotic and cardioprotective activities. Chitoheptaose heptahydrochloride significantly enhances the growth and photosynthesis parameters of wheat seedlings .

HY-133807A

(Rac)-Benpyrine	TNF Receptor	Inflammation/Immunology
(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research .

HY-152576

CB2R agonist 1	Cannabinoid Receptor	Inflammation/Immunology
CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC₅₀ value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role .

HY-N7697A

Chitopentaose pentahydrochloride	Others	Inflammation/Immunology
Chitopentaose pentahydrochloride is a chitosan oligosaccharide with anti-inflammatory effect. Chitopentaose pentahydrochloride is a substrate of gene encoding chitinase B (FjchiB) .

HY-152581

CB2R antagonist 3	Cannabinoid Receptor	Inflammation/Immunology
CB2R antagonist 3 is a selective antagonist of cannabinoid type 2 receptor (CB2R). CB2R antagonist 3 has high affinity for human CB2R and specific selectivity for CB1R. CB2R antagonist 3 can be combined with CB65 (HY-110047), the activator of CB2R. CB2R antagonist 3 effectively up-regulates the expression of anti-inflammatory cytokines and down-regulates the expression of pro-inflammatory cytokines .

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2294A

pm26TGF-β1 peptide TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-155762

Anti-neuroinflammation agent 1	NOD-like Receptor (NLR) Interleukin Related	Neurological Disease Inflammation/Immunology
Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype .

Cat. No.	Product Name	Target	Research Area

HY-P1194

Spantide I	Neurokinin Receptor	Inflammation/Immunology
Spantide I, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P1194A

Spantide I TFA	Neurokinin Receptor	Inflammation/Immunology
Spantide I TFA, a substance P analog, is a selective NK₁ receptor antagonist, with K_i values of 230 nM and 8150 nM for NK₁ and NK₂ receptor, respectively. Spantide I provides an approach to reduce type 1 and enhance the type 2 cytokine IL-10 in the infected cornea, leading to a significant reduction in corneal perforation .

HY-P2294A

pm26TGF-β1 peptide TFA 1 Publications Verification	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 TFA peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide TFA shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide TFA displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

HY-P2320

IDR-1	Bacterial	Infection Inflammation/Immunology
IDR-1 is an antimicrobial peptide that is active against Gram-positive and Gram-negative bacteria. IDR-1 counters infection by selective modulation of innate immunity without obvious toxicities. IDR-1 has anti-inflammatory and anti-infective properties, enhances the levels of monocyte chemokines, and attenuates pro-inflammatory cytokine release .

HY-P2294

pm26TGF-β1 peptide	TGF-β Receptor	Inflammation/Immunology
pm26TGF-β1 peptide is a peptide that mimics a portion of the human TGF-β1 molecule. pm26TGF-β1 peptide shows high affinity for the TGF-β1 receptor. pm26TGF-β1 peptide displays potent anti-inflammatory properties and does not exhibit neutrophils’ chemoattraction .

Cat. No.	Product Name	Target	Research Area

HY-P990001

Anti-Mouse IL-10 Antibody

Interleukin Related Inflammation/Immunology

Anti-Mouse IL-10 Antibody is an IgG1 antibody inhibitor against mouse IL-10. Derived from rat.

HY-P99198

Fletikumab NNC 0109-0012	Interleukin Related	Inflammation/Immunology
Fletikumab (NNC0109-0012) is a monoclonal antibody targeting to IL-20. Fletikumab can be used for inflammation research, such as rheumatoid arthritis .

HY-P990228

*Anti-Mouse IL-10R/CD210 Antibody (1B1.3A)*	Inhibitory Antibodies	Others
Anti-Mouse IL-10R/CD210 Antibody (1B1.3A) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-10R/CD210.

Recombinant Proteins Recommended:

IL-10

Species:	Human (14) Rhesus Macaque (2) Mouse (9) Rat (3) Cynomolgus (2) Pig (2)
Tag:	His (16) Tag Free (10) Avi (5) Fc (8)
Source:	HEK293 (21) CHO (3) E. coli (9)

Cat. No.	Compare	Product Name	Species	Source

HY-P700188AF

	*Animal-Free IL-10* Protein, Mouse (His)** Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF	Mouse	E. coli
	IL-10 protein is a key immunomodulator that, by binding to its heterotetrameric receptors (IL10RA and IL10RB), activates JAK1 and STAT2 (the latter phosphorylates STAT3), thereby triggering potent anti-inflammatory effects. Phosphorylated STAT3 translocates to the nucleus and promotes the expression of anti-inflammatory mediators. Animal-Free IL-10 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-10 Protein, Mouse (His) is 160 a.a., with molecular weight of ~19.69 kDa.

HY-P70517

	IL-10 Protein, Mouse 2 Publications Verification Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF;	Mouse	E. coli
	IL-10 protein is a key immunomodulator that, by binding to its heterotetrameric receptors (IL10RA and IL10RB), activates JAK1 and STAT2 (the latter phosphorylates STAT3), thereby triggering potent anti-inflammatory effects. Phosphorylated STAT3 translocates to the nucleus and promotes the expression of anti-inflammatory mediators. IL-10 Protein, Mouse is the recombinant mouse-derived IL-10 protein, expressed by E. coli , with tag free. The total length of IL-10 Protein, Mouse is 160 a.a., with molecular weight of 15-17 kDa.

HY-P70751

	IL-10 Protein, Human (HEK293) Interleukin-10; IL-10; Cytokine synthesis inhibitory factor; CSIF; IL10; RP11-262N9.1; IL10A; MGC126450; MGC126451; TGIF	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with tag free. The total length of IL-10 Protein, Human (HEK293) is 160 a.a., with molecular weight of 16-20 kDa.

HY-P7030

IL-10 Protein, Human

rHuIL-10; CSIF
Human E. coli

IL-10 Protein, Human is an anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P700244AF

	*Animal-Free IL-10* Protein, Pig (His)** Interleukin-10; IL10; IL-10; Cytokine synthesis inhibitory factor; CSIF	Pig	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. Animal-Free IL-10 Protein, Pig (His) is the recombinant pig-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-10 Protein, Pig (His) is 157 a.a., with molecular weight of ~19.1 kDa.

HY-P7030A

	IL-10 Protein, Human (CHO) 2 Publications Verification rHuIL-10; CSIF	Human	CHO
	IL-10 Protein, Human (CHO) is a CHO cell derived anti-inflammatory, immunomodulatory cytokine that regulates mucosal inflammation.

HY-P7098A

	IL-10 Protein, Rat (CHO) 1 Publications Verification rRtIL-10; CSIF	Rat	CHO
	IL-10 Protein, Rat (CHO) is a CHO cell derived immunosuppressive cytokine produced by a variety of mammalian cell types including macophages, monocytes, B-cells, T-cells and keratinocytes.

HY-P7074A

	IL-10 Protein, Mouse (CHO) rMuIL-10; CSIF	Mouse	CHO
	IL-10 Protein, Mouse (CHO) is a potent CHO cell derived anti-inflammatory cytokine results in increased immune-mediated demyelination in mice infected with a neurotropic coronavirus.

HY-P73154

	IL-10 Protein, Pig Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Pig	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. IL-10 Protein, Pig is the recombinant pig-derived IL-10 protein, expressed by E. coli , with tag free. The total length of IL-10 Protein, Pig is 157 a.a., with molecular weight of ~18.0 kDa.

HY-P73152

	IL-10 Protein, Feline Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Others	E. coli
	IL-10 Protein, a key immune regulator, mitigates inflammation by binding to its receptor (IL10RA/IL10RB), activating JAK1 and STAT2, leading to STAT3-mediated anti-inflammatory gene expression. IL-10 targets APCs, reducing pro-inflammatory cytokines and hindering antigen presentation. It controls macrophage inflammation through metabolic reprogramming. Existing as a homodimer, IL-10 interacts with IL10RA/IL10RB. IL-10 Protein, Feline is the recombinant IL-10 protein, expressed by E. coli , with tag free. The total length of IL-10 Protein, Feline is 160 a.a., with molecular weight of ~19 kDa.

HY-P73153

	IL-10 Protein, Human (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag. The total length of IL-10 Protein, Human (HEK293, His) is 160 a.a., with molecular weight of ~20.9 kDa.

HY-P700740

	IL-10 Protein, Cynomolgus (HEK293, His) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Cynomolgus	HEK293
	IL-10 Protein, a key immune regulatory cytokine, centrally modulates immune responses. IL-10 Protein, Cynomolgus (HEK293, His) is the recombinant cynomolgus-derived IL-10 protein, expressed by HEK293 , with N-His labeled tag. The total length of IL-10 Protein, Cynomolgus (HEK293, His) is 160 a.a., with molecular weight of 20-22 kDa.

HY-P78460

	IL-10 Protein, Human (HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-10 Protein, Human (HEK293, His-Avi) is 160 a.a., with molecular weight of 23-25 kDa.

HY-P78144

	IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) Interleukin-10; IL-10; CSIF; IL10A; TGIF; B-TCGF; GVHDS; MGC126450; MGC126451	Human	HEK293
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-10 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-10 Protein, Human (Biotinylated, HEK293, His-Avi) is 160 a.a., with molecular weight of 23-25 kDa.

HY-P700741

IL-10R alpha Protein, Cynomolgus (HEK293, His)

IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha
Cynomolgus HEK293

HY-P78464

	IL-10R alpha Protein, Human (HEK293, His-Avi) IL-10RA; IL10RA; IL10R; IL-10R1; IL-10R subunit 1; CDw210a; HIL-10R; IBD28; IL-10 R alpha	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His-Avi) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a His and Avi tag at the C-terminus.

HY-P70692

	IL-10R alpha Protein, Human (HEK293, His) Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a 6*His tag at the C-terminus.

HY-P700639

	IL-10R alpha Protein, Human (HEK293) Interleukin-10 receptor subunit alpha; IL-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R subunit 1; IL-10R1; CD210; IL10RA	Human	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (V236-L256) with a 6*His tag at the C-terminus.

HY-P75825

	IL-10R alpha Protein, Mouse (HEK293, Fc) Interleukin-10 receptor subunit alpha; IL-10R subunit alpha; IL-10RA; CDw210a; Interleukin-10 receptor subunit 1; IL-10R1; CD210; IL10RA	Mouse	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Mouse (HEK293, Fc) is expressed by HEK 293 cells and has a transmembrane region (L242-I262) with a -hFc tag at the C-terminus.

HY-P72599

	IL-10R beta Protein, Human (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Human (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W221-F242) with a 6*His tag at the C-terminus.

HY-P74837

	IL-10R beta Protein, Mouse (HEK293, His) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Mouse	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, His) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a His tag at the C-terminus.

HY-P74838

	IL-10R beta Protein, Mouse (HEK293, hFc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Mouse	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Mouse (HEK293, hFc) is expressed by HEK 293 cells and has a transmembrane region (W223-Y251) with a hFc tag at the C-terminus.

HY-P76414

	IL-10R beta Protein, Rat (HEK293, Fc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Rat	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses.IL-10R beta Protein, Rat (HEK293, Fc) is expressed by HEK 293 cells and consists of 351 amino acids (M1-V351) with a Fc tag at the C-terminus.

HY-P76987

	IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc) Interleukin-10 receptor subunit alpha; IL-10RA; CDw210a; IL-10R1; CD210	Rhesus Macaque	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines.IL-10R alpha Protein, Rhesus Macaque (HEK293, Fc) is expressed in HEK 293 cells and consists of 590 amino acids (M1-S590) with a -hFc tag at the C-terminus.

HY-P76988

	IL-10R alpha Protein, Rhesus Macaque (HEK293, His) Interleukin-10 receptor subunit alpha; IL-10RA; CDw210a; IL-10R1; CD210	Rhesus Macaque	HEK293
	IL-10R alpha protein is an IL10 cytokine surface receptor that is involved in IL10-mediated inflammation and immune regulation and inhibits the synthesis of pro-inflammatory cytokines. IL-10R alpha Protein, Rhesus Macaque (HEK293, His) is expressed in HEK 293 cells and consists of 590 amino acids (M1-S590) with a His tag at the C-terminus.

HY-P74839

	IL-10R beta Protein, Human (HEK293, His-hFc) Interleukin-10 receptor subunit beta; IL-10RB; CRF2-4; IL-10R2; CDw210b	Human	HEK293
	IL-10R beta protein is an IL10 cytokine surface receptor involved in IL10-mediated inflammation and immune regulation, as well as viral defense responses. IL-10R beta Protein, Human (HEK293, His-hFc) is expressed by HEK 293 cells and has a transmembrane region (W221-F242) with a His and -hFc tag at the C-terminus.

HY-P701062

	*IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi)* IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
	Interleukin 10 receptor beta (IL-10Rβ) is an important component of the interleukin 10 (IL-10), IL-22 and IL-24 receptor complex and plays a central role in mediating multiple signaling pathways effect. As part of the IL-10 receptor, IL-10Rβ forms a functional heterodimer with IL-10Rα and initiates IL-10 signaling through the JAK/STAT pathway. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P700872

	*IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi)* IL-22R alpha 1; IL-10R beta; IL-22Rα1&IL-10Rβ	Human	HEK293
	Interleukin-10 Receptor Beta (IL-10Rβ) is a crucial component of the receptor complexes for interleukin-10 (IL-10), IL-22, and IL-24, playing a central role in mediating diverse signaling pathways. As part of the IL-10 receptor, IL-10Rβ forms functional heterodimers with IL-10Rα, initiating IL-10 signaling through the JAK/STAT pathways. Additionally, in collaboration with IL-22Rα1, IL-20RB, and IL-22BP, IL-10Rβ contributes to IL-22 and IL-24 signaling, activating various downstream pathways. The IL-10Rβ-containing receptor complex plays a pivotal role in modulating immune responses and maintaining cellular homeostasis. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi) is a recombinant protein dimer complex containing human-derived IL-22R alpha 1 & IL-10R beta protein, expressed by HEK293, with C-Avi, C-hFc labeled tag. IL-22R alpha 1 & IL-10R beta Protein, Human (Biotinylated, HEK293, hFc-Avi), has molecular weight of 68-75 kDa.

HY-P73892

	IL-20 Protein, Rat Cytokine Zcyto10; IL10D; IL20; Interleukin-20	Rat	E. coli
	IL-20 Protein, a pivotal immune regulatory cytokine, critically modulates immune responses. IL-20 Protein, Rat is the recombinant rat-derived IL-20 protein, expressed by E. coli , with tag free. The total length of IL-20 Protein, Rat is 152 a.a., with molecular weight of ~17 kDa.

HY-P77963

	IL-20 Protein, Mouse (HEK293, Fc) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	HEK293
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-hFc labeled tag. The total length of IL-20 Protein, Mouse (HEK293, Fc) is 152 a.a., with molecular weight of 45-50 kDa.

HY-P77964

	IL-20 Protein, Mouse (HEK293, His) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	HEK293
	IL-20 protein is secreted by monocytes and skin keratinocytes and is a proinflammatory cytokine critical for immune responses, inflammatory regulation, hematopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-20 protein, expressed by HEK293 , with N-His labeled tag. The total length of IL-20 Protein, Mouse (HEK293, His) is 152 a.a., with molecular weight of 20-22 kDa.

HY-P700198AF

	Animal-Free IL-20 Protein, Mouse (His) IL-20; Cytokine Zcyto10; Zcyto10; IL10D; MGC96907	Mouse	E. coli
	IL-20 Protein, secreted by monocytes and skin keratinocytes, is a pro-inflammatory cytokine crucial for immune responses, inflammatory regulation, hemopoiesis, and epidermal cell differentiation. It enhances tissue remodeling and wound healing, maintaining epithelial integrity during infection. IL-20 Protein impacts actin-mediated functions in neutrophils, inhibiting phagocytosis, granule exocytosis, and migration. It signals through IL20RA/IL20RB or IL22RA1/IL20RB complexes, activating JAK2, STAT5, AKT, and ERK1/2 phosphorylations. In keratinocytes, it activates STAT3 in a JAK2, ERK1/2, and p38 MAPK-dependent manner, forming a heterotrimeric complex with its receptor IL20RA/IL20RB. Animal-Free IL-20 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-20 protein, expressed by E. coli, with C-His labeled tag. The total length of Animal-Free IL-20 Protein, Mouse (His) is 152 a.a., with molecular weight of ~18.52 kDa.

HY-P700097AF

	*Animal-Free IL-10* Protein, Human (His)** B-TCGF; CSIF; TGIF	Human	E. coli
	IL-10 protein is a major immunoregulatory cytokine with profound anti-inflammatory functions that limits excessive tissue destruction caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptors IL10RA and IL10RB, leading to JAK1- and STAT2-mediated phosphorylation of STAT3, which translocates to the nucleus and drives the expression of anti-inflammatory mediators. Animal-Free IL-10 Protein, Human (His) is the recombinant human-derived animal-FreeIL-10 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-10 Protein, Human (His) is 160 a.a., with molecular weight of ~19.6 kDa.

Cat. No.	Product Name	Application	Reactivity

HY-P81113

IL-10 Antibody Interleukin-10 precursor; Cytokine synthesis inhibitory factor; CSIF; Cytokine Synthesis Inhibitory Factor; IL 10; IL10A; Interleukin 10; Interleukin10; MGC126450; MGC126451; TGIF; IL10_HUMAN. 白介素10	WB; ELISA; IHC-P; IHC-F; IF	Human, Mouse(predicted: Rat, Chicken, Pig, Rabbit, Sheep, Guinea Pig)
IL-10 Antibody is an unconjugated, approximately 18 kDa, rabbit-derived, anti-IL-10 polyclonal antibody. IL-10 Antibody can be used for: WB, ELISA, IHC-P, IHC-F, IF expriments in human, mouse, and predicted: rat, chicken, pig, rabbit, sheep, guinea pig background without labeling.

HY-P81240

IL-19 Antibody

IL-19; MDA1; NG.1; ZMDA1; IL-10C
WB, IHC-P Human

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