IL-19 Antibody
(Synonyms: IL-19; MDA1; NG.1; ZMDA1; IL-10C)IL-19 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL-19.
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Host:
Rabbit
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Isotype:
IgG
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Application:
WB, IHC-P
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Reactivity :
Human
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Formulation:
Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:50-1:100 |
Product Details
IL-19 Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to IL-19.
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Host Rabbit
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Clonality Polyclonal
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Species ReactivityHuman
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Observed Molecular WeightObserved band size: 20 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 20 kDa
Synthetic peptide of human IL19
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
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Appearance
Solution
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Formulation
Supplied in pH 7.4 PBS, 0.05% NaN3, 40% Glycerol.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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Envío
Shipping with blue ice.
Background
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Function
IL-19 is a Cytokine that functions as an anti-inflammatory and proangiogenic factor. Polarizes adaptive immunity to an anti-inflammatory phenotype through induction of T-helper 2 responses by both down-regulation of IFN-gamma and up-regulation of IL4 and IL13. Produced by osteocytes, stimulates granulopoiesis and neutrophil formation. Exerts its biological effect through a receptor complex consisting of a heterodimer of IL20RA and IL20RB. In turn, activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, and importantly, STAT3[1][2][3][4].
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Subcellular Localization
Secreted
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Expression
Induction:by DNA damage through pathways mediated by JUN and cGAS-STING leading to production of the cytokines IL1, IL6, and IL8 -
Isoforms & Post-Translational Modification
Q9UHD0 has 3 isomers: Q9UHD0-1: 20452 Da (predicted); Q9UHD0-2: 24568 Da (predicted); Q9UHD0-3: 23079 Da (predicted).
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SwissProt ID
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Synonyms
IL-19; MDA1; NG.1; ZMDA1; IL-10C
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Research Field
Immunology
Documentación
[1]. Small SH, et al. Induction of IL19 expression through JNK and cGAS-STING modulates DNA damage-induced cytokine production. Sci Signal. 2021 Dec 21;14(714):eaba2611. [Content Brief]
[2]. Oral HB, et al. Regulation of T cells and cytokines by the interleukin-10 (IL-10)-family cytokines IL-19, IL-20, IL-22, IL-24 and IL-26. Eur J Immunol. 2006 Feb;36(2):380-8. [Content Brief]
[3]. Parrish-Novak J, et al. Interleukins 19, 20, and 24 signal through two distinct receptor complexes. Differences in receptor-ligand interactions mediate unique biological functions. J Biol Chem. 2002 Dec 6;277(49):47517-23. [Content Brief]
[4]. Dumoutier L, et al. Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types. J Immunol. 2001 Oct 1;167(7):3545-9. [Content Brief]
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