IL19 - interleukin 19 Gene

Also Known as MDA1; NG.1; ZMDA1; IL-10C

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29949

About IL19

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,770,773-206,842,981 (from NCBI)

This gene has 6 transcripts (splice variants), 185 orthologues and 4 paralogues. Low expression observed in reference dataset.

Summary

The protein encoded by this gene is a cytokine that belongs to the IL10 cytokine subfamily. This cytokine is found to be preferentially expressed in monocytes. It can bind the IL20 receptor complex and lead to the activation of the signal transducer and activator of transcription 3 (STAT3). A similar cytokine in mouse is reported to up-regulate the expression of IL6 and TNF-alpha and induce Apoptosis, which suggests a role of this cytokine in inflammatory responses. Alternatively spliced transcript variants encoding the distinct isoforms have been described. [provided by RefSeq, Jul 2008]

IL19 Products (5)

mRNA Protein Name
NM_001369605.1 NP_001356534.1 interleukin-19 precursor
NM_001393490.1 NP_001380419.1 interleukin-19 precursor
NM_001393491.1 NP_001380420.1 interleukin-19 precursor
NM_013371.5 NP_037503.2 interleukin-19 precursor
NM_153758.5 NP_715639.2 interleukin-19 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
22802649 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL19 Protein Structure

IL10

IL10: Interleukin 10 (34 - 168)

  • 0
  • 100
  • 177 a.a.
Protein Preferred Names Protein Names

interleukin-19

  • melanoma differentiation associated protein-like protein

Recombinant IL19 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P7212 IL-19 Protein, Human Q9UHD0-1 (L25-A177, F175S) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73183 IL-19 Protein, Human (sf9, His) Q9UHD0-1 (L25-A177) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P73184 IL-19 Protein, Human (HEK293, His) Q9UHD0-1 (L25-A177) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P700109AF Animal-Free IL-19 Protein, Human (His) AAK91776.1 (L63-A215) ≥ 95%, as determined by reducing SDS-PAGE.

IL19 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81240 IL-19 Antibody WB, IHC-P Human

Related Diseases

Diseases Alias
Human Immunodeficiency Virus Type 1

  • Aids

  • Hiv/Aids

  • Aids, Delayed/Rapid Progression To

  • Hiv-1, Susceptibility To

  • Hiv-1 Viremia, Susceptibility To

  • Human Immunodeficiency Virus Type 1, Susceptibility To

  • Hiv-1

  • Aids, Slow Progression To

  • Rapid Progression To Aids From Hiv1 Infection

  • Hiv1 Infection, Resistance To

  • Hiv1 Infection

  • Hiv-1 Viremia

  • Aids, Resistance To

  • Aids, Rapid Progression To

  • Hiv/Aids, Susceptibility To

  • Hiv-1, Resistance To

  • Hiv1, Resistance To

  • Hiv1

  • Hiv-1 Disease, Delayed Progression Of

  • Hiv-1 Disease, Rapid Progression Of

  • Hiv Infection, Resistance To

  • Hiv Type 1, Susceptibility To

  • Hiv Type 1

  • Hiv-1 Infection

  • Human Immunodeficiency Virus I Infection

  • Acquired Immunodeficiency Syndrome

  • Hiv-Infection/Aids
Psoriasis
Fungal Esophagitis
Psoriasis 12

  • PSORS12

  • Psoriasis Susceptibility 12

  • Psoriasis 12, Susceptibility To
Pustulosis Of Palm And Sole

  • Psoriasis

  • Acropustulosis

  • Palmoplantar Pustulosis

  • Pustular Psoriasis Of The Palms And/Or Soles

  • Pustulosis Of Palms And Soles

  • Acrodermatitis Continua Of Hallopeau

  • Generalized Pustular Psoriasis
Chronic Recurrent Multifocal Osteomyelitis

  • Chronic Multifocal Osteomyelitis

  • CRMO

  • Cmo

  • Cno/Crmo

  • Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis

  • Osteomyelitis, Chronic Multifocal

  • Multifocal Osteomyelitis, Chronic

  • Chronic Osteomyelitis

  • Chronic Multifocal Osteomyelitis, Unspecified Site

  • Crmo - [Chronic Multifocal Osteomyelitis]

  • Chronic Osteomyelitis With Draining Sinus, Unspecified Site

  • Bone Fistula With Chronic Osteomyelitis
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Psoriasis 14, Pustular

  • Generalized Pustular Psoriasis

  • Gpp

  • Ditra

  • Acrodermatitis Continua Of Hallopeau

  • Palmoplantar Pustulosis

  • PSORS14

  • Interleukin 36 Receptor Antagonist Deficiency

  • Psorp

  • Pustular Psoriasis 14

  • Deficiency Of Il-36r Antagonist

  • Acute Generalised Pustular Psoriasis

  • Deficiency Of The Interleukin-36 Receptor Antagonist

  • Generalized Pustular Psoriasis Of Von Zumbusch

  • Von Zumbusch Psoriasis

  • Deficiency Of Il-36ra

  • Psoriasis, Pustular, Generalized

  • Psoriasis, Pustular, Type 14

  • Pustulosis Of Palms And Soles

  • Acute Generalized Pustular Psoriasis

  • Palmoplantar Pustular Psoriasis

  • Pustulosis Palmaris Et Plantaris

  • Ppp - [Palmoplantar Pustulosis]

  • Pustular Psoriasis Of The Palms And Soles

  • Pustular Bacterid
Autoimmune Disease

  • Autoimmune Diseases

  • Autoimmune Hypersensitivity Disease

  • Hypersensitivity Reaction Type Ii Disease

  • Type Ii Hypersensitivity Reaction Disease
Autoimmune Disease Of Skin And Connective Tissue
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Skin Disease

  • Skin Diseases

  • Genodermatosis

  • Abnormality Of The Skin

  • Skin Diseases, Genetic

  • Skin And Subcutaneous Tissue Disease

  • Dermatologic Disorders
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06712 IL19 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174629 Human IL19 mRNA / Unkown
HY-RS17267 Il19 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23721 Il19 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P992240 Anti-IL-19 Antibody / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus IL19 VGNC VGNC:107882
Bos taurus IL19 VGNC VGNC:30129
Canis familiaris IL19 VGNC VGNC:41955
Macaca mulatta IL19 VGNC VGNC:99979
Mus musculus IL19 MGD MGI:1890472
Rattus norvegicus IL19 RGD RGD:1583546
Others IL19 NCBI