1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-19
  5. IL-19 Protein, Human (HEK293, His)

IL-19 Protein, Human (HEK293, His)

Cat. No.: HY-P73184
Handling Instructions

IL-19 protein acts as an anti-inflammatory and pro-angiogenic cytokine. IL-19 Protein, Human (HEK293, His) is the recombinant human-derived IL-19 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-19 Protein, Human (HEK293, His) is 177 a.a., with molecular weight of ~19.2 kDa.

For research use only. We do not sell to patients.

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Description

IL-19 protein acts as an anti-inflammatory and pro-angiogenic cytokine. IL-19 Protein, Human (HEK293, His) is the recombinant human-derived IL-19 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-19 Protein, Human (HEK293, His) is 177 a.a., with molecular weight of ~19.2 kDa.

Background

The IL-19 Protein serves a dual role as an anti-inflammatory and proangiogenic factor. It plays a crucial role in shaping adaptive immunity towards an anti-inflammatory phenotype by inducing T-helper 2 responses, achieved through the down-regulation of IFN-gamma and the up-regulation of IL4 and IL13. Produced by osteocytes, IL-19 also contributes to granulopoiesis and the formation of neutrophils. Its biological effects are mediated through a receptor complex comprising the IL20RA and IL20RB heterodimer. Upon binding, IL-19 activates the Janus kinase (JAK) and signal transducer and activator of transcription (STAT) pathway, particularly emphasizing STAT3 activation, highlighting its pivotal role in diverse immunomodulatory functions.

Species

Human

Source

HEK293

Tag

C-His

Accession

Q9UHD0 (M1-A177)

Gene ID
Synonyms
Interleukin-19; IL-19; IL19; ZMDA1
Molecular Weight

Approximately 19.2 kDa

Purity

Greater than 95% as determined by reducing SDS-PAGE.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Documentation

IL-19 Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-19 Protein, Human (HEK293, His)
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HY-P73184
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