2. Immunology/Inflammation Stem Cell/Wnt
  3. Interleukin Related Wnt
  4. 1,11b-Dihydro-11b-hydroxymedicarpin

1,11b-Dihydro-11b-hydroxymedicarpin  (Synonyms: 11b-Hydroxy-11b,1-dihydromedicarpin)

Cat. No.: HY-N0976
Instrucciones de manejo Technical Support

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice.

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1,11b-Dihydro-11b-hydroxymedicarpin

1,11b-Dihydro-11b-hydroxymedicarpin Estructura química

No. CAS : 210537-04-5

Tamaño Precio Stock Cantidad
1 mg Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
5 mg Obtener un presupuesto 2 - 3 Weeks 1 - 2 Weeks 3 - 4 Weeks 2 - 3 weeks
10 mg   Obtener un presupuesto  
50 mg   Obtener un presupuesto  
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1,11b-Dihydro-11b-hydroxymedicarpin Related Antibodies

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Wnt1 Wnt2 Wnt3 Wnt5 Wnt7 Wnt11

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Descripciòn

1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].

Cellular Effect
Cell Line Type Value Description References
U-937 IC50
>100 μM
Compound: 22
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 24 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
>100 μM
Compound: 22
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 48 hrs by WST-8 assay
[PMID: 17158054]
U-937 IC50
>100 μM
Compound: 22
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
Antiproliferative activity against human U937 cells after 72 hrs by WST-8 assay
[PMID: 17158054]
Peso molecular

288.30

Fòrmula

C16H16O5
No. CAS
SMILES

O=C(CC1)C=C2[C@@]1(O)[C@@](OC3=CC(OC)=CC=C34)([H])[C@@]4([H])CO2
Structure Classification
Initial Source
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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1,11b-Dihydro-11b-hydroxymedicarpin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,11b-Dihydro-11b-hydroxymedicarpin210537-04-511b-Hydroxy-11b,1-dihydromedicarpinInterleukin RelatedWntILpterocarpaninflammatoryInhibitorinhibitorinhibit

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Nombre del producto:
1,11b-Dihydro-11b-hydroxymedicarpin
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