210537-04-5
Chemical Structure
1,11b-Dihydro-11b-hydroxymedicarpin
Synonym(s): 11b-Hydroxy-11b,1-dihydromedicarpin
- CAS No.: 210537-04-5
- Formula:C16H16O5
- Molecular Weight:288.30
IUPAC Name: (6aR,11aR,11bS)-11b-hydroxy-9-methoxy-1,2,6,6a,11a,11b-hexahydro-3H-benzofuro[3,2-c]chromen-3-one
InChIKey: XIJBDLYFYFZZDS-APHBMKBZSA-N
SMILES: O=C(CC1)C=C2[C@@]1(O)[C@@](OC3=CC(OC)=CC=C34)([H])[C@@]4([H])CO2
Biological Activity: 1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative[1]. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways[2]. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice[3].
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1,11b-Dihydro-11b-hydroxymedicarpin | 1,11b-Dihydro-11b-hydroxymedicarpin (11b-Hydroxy-11b,1-dihydromedicarpin) is a pterocarpan from Ononis viscosa subsp. breviflora is a Medicarpin derivative. Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of Notch and Wnt canonical signaling pathways. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Medicarpin down-regulates pro-inflammatory cytokines like TNF-α, IL-6 and IL-17A, while up-regulates anti-inflammatory cytokine IL-10 in arthritis (CIA) model of mice. | |||||||||||||||||||||
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References
- [1]. Alejandro F.Barrero, et al. Pterocarpans from Ononis viscosa subsp. breviflora. Phytochemistry. 1998 May, 48 (1): 187-190.
- [2]. Manisha Dixit, et al. Medicarpin, a Natural Pterocarpan, Heals Cortical Bone Defect by Activation of Notch and Wnt Canonical Signaling Pathways. PLoS One. 2015 Dec 11;10(12):e0144541. [Content Brief]
- [3]. Mohd Nizam Mansoori, et al. Medicarpin prevents arthritis in post-menopausal conditions by arresting the expansion of TH17 cells and pro-inflammatory cytokines. Int Immunopharmacol. 2020 Feb 22;82:106299. [Content Brief]
