1. Immunology/Inflammation
    Apoptosis
  2. Interleukin Related
    Caspase
  3. Ossirene

Ossirene (Synonyms: AS101)

Cat. No.: HY-101019
Handling Instructions

Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies.

For research use only. We do not sell to patients.

Ossirene Chemical Structure

Ossirene Chemical Structure

CAS No. : 106566-58-9

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ossirene (AS101), an immunomodulatory tellurium compound, is a potent IL-1β inhibitor[1]. Ossirene abolishes phosphorylation of STAT3 by inhibiting IL-10. Ossirene potently inhibits Caspase-1 and is used for the autoimmune diseases and certain malignancies[2][3][4].

IC50 & Target[1][2][4]

IL-1β

 

IL-10

 

Caspase-1

 

In Vitro

Ossirene (AS101; 1 μg/mL; for 24 hours) almost completely abrogates expression of pStat3. Ossirene may reduce expression of Bcl-2 after inhibition of Stat3 activation via IL-10 inhibition[2].
AS101 (0.5, 5 mg/mL; 24 hours) inhibits IL-1β-induced mRNA expression of inflammatory mediators in the RPE in a dose-dependent manner. AS101 inhibits IL-1β-induced mRNA expression and protein production of IL-6 and IL-8 in RPE cells. AS101 (5 mg/mL; 1 hour) inhibits the phosphorylation of the p65 component of the NFκB complex activated by IL-1β[1].
Ossirene (0.1, 0.5, 1, 2.5 μg/mL) significantly decreases B16 melanoma, stomach adenocarcinoma, and human glioblastoma multiforme (GBM) cells proliferation[2].
AS101 (0.5 μg/mL; for 24 hours) sensitizes GBM tumor cells to paclitaxel in an IL-10-dependent manner[2].

Western Blot Analysis[2]

Cell Line: B16 melanoma cells
Concentration: 1 μg/mL
Incubation Time: For 24 hours
Result: Almost completely abrogated expression of pStat3.

RT-PCR[1]

Cell Line: ARPE19 cells
Concentration: 0.5, 5 mg/mL
Incubation Time: 24 hours
Result: Inhibited IL-1β-induced mRNA expression of inflammatory mediators in the RPE in a dose-dependent manner.
In Vivo

Ossirene (AS101; 0.5 mg/kg/day; IP; 25 days) sensitizes GBM tumors to paclitaxel via inhibition of IL-10, resulting in increased survival[2].

Animal Model: SCID mice with GBM cells[2]
Dosage: 0.5 mg/kg
Administration: IP; daily; 25 days
Result: Significantly increased survival of GBM tumor-bearing mice.
Molecular Weight

312.05

Formula

C₂H₈Cl₃NO₂Te

CAS No.

106566-58-9

SMILES

[Cl-][Te+4]1([Cl-])([Cl-])[O-]CC[O-]1.[NH4+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

OssireneAS101AS 101AS-101Interleukin RelatedCaspaseILimmunomodulatorytelluriumphosphorylationSTAT3autoimmunediseasesmalignanciesIL-6IL-8RPEp65NFκBInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Ossirene
Cat. No.:
HY-101019
Quantity:
MCE Japan Authorized Agent: