RPE

By Targets:	Amino Acid Derivatives (2) Apoptosis (3) Autophagy (2) Bacterial (1) Complement System (1) DNA Stain (1) Ferroptosis (1) Fluorescent Dye (2) Fungal (1) HDAC (1) Phospholipase (1) PKC (1) Reactive Oxygen Species (2) ROCK (1) Small Interfering RNA (siRNA) (2) VEGFR (1)
By Research Areas:	Cancer (6) Cardiovascular Disease (2) Infection (3) Inflammation/Immunology (6) Metabolic Disease (1) Neurological Disease (1)
Click Chemistry:	Alkynes (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0988

R-PE (R-Phycoerythrin)	Fluorescent Dye	Others
R-Phycoerythrin is a phycobiliproteins could be isolated from Heterosiphonia japonica. R-Phycoerythrin is a potent fluorescent probe contains four chromophore-carrying subunits that exhibits extremely bright red-orange fluorescence. (λex=496 nm, λem=578 nm) .

HY-22024

5-Hydroxyflavone

Others Cancer

5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .
HY-149325

RPE65-IN-1

Others Others

RPE65-IN-1(Compound 16e) is a potent RPE65 inhibitor, which can be used in retinopathy-related research .

5-Hydroxyflavone	Others	Cancer
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

RPE65-IN-1	Others	Others
RPE65-IN-1(Compound 16e) is a potent *RPE65* inhibitor, which can be used in retinopathy-related research .

HY-RS12150

RPE Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPE Human Pre-designed siRNA Set A contains three designed siRNAs for RPE gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPE Human Pre-designed siRNA Set A RPE Human Pre-designed siRNA Set A

HY-RS12151

RPE65 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
RPE65 Human Pre-designed siRNA Set A contains three designed siRNAs for RPE65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

RPE65 Human Pre-designed siRNA Set A RPE65 Human Pre-designed siRNA Set A

HY-N11499

Myricetin 3-O-α-L-arabinopyranoside	Bacterial	Infection Inflammation/Immunology
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models .

HY-N0428

Obacunone	Apoptosis	Cancer
Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-148457

Avacincaptad pegol	Complement System	Infection Inflammation/Immunology
Avacincaptad pegol, which is a pegylated aptamer, has garnered significant attention as a C5 complement inhibitor that may reduce inflammation-related retinal pigment epithelium (RPE) damage. Avacincaptad pegol caqn be used for the research of stargardt macular dystrophy (STGD1) and geographic atrophy (GA) .

HY-101293

VU0359595 CID-53361951; ML-270	Phospholipase Fungal	Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
VU0359595 (CID-53361951; ML-270) is a potent and selective pharmacological phospholipase D1 (PLD1) inhibitor with an IC₅₀ of 3.7 nM. VU0359595 is >1700-fold selective for PLD1 over PLD2 (IC₅₀ of 6.4 μM). VU0359595 can be used for the research of cancer, diabetes, neurodegenerative and inflammatory diseases .

HY-D1742

DRAQ5	Fluorescent Dye DNA Stain	Others
DRAQ5 is a novel cell permeant and far red-fluorescing DNA probe. DRAQ5 excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DRAQ5 fluorescence reflects cellular DNA content. DRAQ5 can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .

HY-125639

(rac)-AR-13503 (rac)-AR-13324 M1 metabolite	PKC ROCK	Cardiovascular Disease
(rac)-AR-13503 ((rac)-AR-13324 M1 metabolite) is the isoform of AR-13503 (HY-12798C). AR-13503 a ROCK/PKC inhibitor, inhibiting angiogenesis and enhancing retinal pigment epithelium (RPE) permeability. AR-13503 also inhibits the formation of aberrant neovascularization (NV) in oxygen-induced retinopathy (OIR) model in mice .

HY-134928

Pyridinium bisretinoid A2E A2E	Apoptosis Autophagy Reactive Oxygen Species	Cancer
Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases .

HY-P4253

Arginyl-Glutamine	VEGFR	Cardiovascular Disease
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .

HY-134928A

Pyridinium bisretinoid A2E TFA A2E TFA	Apoptosis Autophagy Reactive Oxygen Species	Cancer
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases .

HY-P5169

LVGRQLEEFL (mouse)	Amino Acid Derivatives	Inflammation/Immunology
LVGRQLEEFL (mouse) can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death .

HY-P5169A

LVGRQLEEFL (mouse) (TFA)	Amino Acid Derivatives	Inflammation/Immunology
LVGRQLEEFL (mouse) TFA can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) TFA exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) TFA can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death .

HY-12462

WS3	Others	Inflammation/Immunology
WS3 is a novel proliferative molecule that promotes pancreatic β cell proliferation in rodent and human primary islets. WS3 can be used for the research of type 1 diabetes .

HY-151872

HDAC-IN-48	HDAC Ferroptosis	Cancer
HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI₅₀~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins . HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Cat. No.	Product Name	Type

HY-D0988

R-PE (R-Phycoerythrin)	Dyes
R-Phycoerythrin is a phycobiliproteins could be isolated from Heterosiphonia japonica. R-Phycoerythrin is a potent fluorescent probe contains four chromophore-carrying subunits that exhibits extremely bright red-orange fluorescence. (λex=496 nm, λem=578 nm) .

HY-D1742

DRAQ5	Fluorescent Dyes/Probes
DRAQ5 is a novel cell permeant and far red-fluorescing DNA probe. DRAQ5 excites at a wavelength of 647 nm, close to the Ex, and produces a fluorescence spectrum extending from 665 nm out to beyond 780 nm wavelengths. DRAQ5 fluorescence reflects cellular DNA content. DRAQ5 can be used in combination with FITC and RPE-labelled antibodies, without the need for fluorescence compensation .

Cat. No.	Product Name	Target	Research Area

HY-P4859

Pyr-Gly

Peptides Others

Pyr-Gly is an inhibitory peptide. Pyr-Gly inhibits proliferation of retinal pigment epithelium (RPE) cells and fibroblasts .

Pyr-Gly	Peptides	Others
Pyr-Gly is an inhibitory peptide. Pyr-Gly inhibits proliferation of retinal pigment epithelium (RPE) cells and fibroblasts .

HY-P4253

Arginyl-Glutamine	VEGFR	Cardiovascular Disease
Arginyl-Glutamine is a dipeptide that can decrease VEGF levels and inhibit retinal neovascularization in a mouse model of oxygen-induced retinopathy .

HY-P5169

LVGRQLEEFL (mouse)	Amino Acid Derivatives	Inflammation/Immunology
LVGRQLEEFL (mouse) can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death .

HY-P5169A

LVGRQLEEFL (mouse) (TFA)	Amino Acid Derivatives	Inflammation/Immunology
LVGRQLEEFL (mouse) TFA can be named as G * peptide, corresponding to amino acids 113 to 122 in apolipoprotein J ([113,122] apoJ)}. LVGRQLEEFL (mouse) TFA exhibits anti-inflammatory and anti-atherogenic properties. LVGRQLEEFL (mouse) TFA can be added to an apoJ mimetic, to form HM-10/10 peptide, which is a mimetic peptide and a novel chimeric high density lipoprotein. HM-10/10 peptide protects retinal pigment epithelium (RPE) and photoreceptors from oxidant induced cell death .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-22024

5-Hydroxyflavone	Flavonoids Monophenols other families Classification of Application Fields Flavones Source classification Phenols Plants Disease Research Fields Cancer	Others
5-Hydroxyflavone, a flavonoid ligand, shows no cytotoxic activity against MCF-7, FaDU, MDA-MB-435S, U87, RPE-1, and HEK293 cells .

HY-N0428

Obacunone	Triterpenes Structural Classification Classification of Application Fields Terpenoids Source classification Rutaceae Plants Disease Research Fields Citrus Cancer	Apoptosis
Obacunone is a highly oxidized triterpenoid limonoid isolated from citrus plants. Obacunone exerts its anticancer effects by inducing apoptosis. Obacunone also protects retinal pigment epithelial (RPE) cells from ultraviolet (UV) radiation (UVR)-induced oxidative damage .

HY-N11499

Myricetin 3-O-α-L-arabinopyranoside	Structural Classification Flavonoids Flavones Source classification Plants Sapotaceae Pouteria torta (Mart.) Radlk.	Bacterial
Myricetin 3-O-α-L-arabinopyranoside is a quercetin derivative and plant flavonoid with antioxidant, antibacterial and antiurease effects. Myricetin 3-O-α-L-arabinopyranoside inhibits A2E photooxidation-induced RPE cell death. Myricetin 3-O-α-L-arabinopyranoside is protective against retinal degeneration and protects against blue light (BL)-induced damage in RPE cells and mouse models .

Species:	Human (2) Mouse (1)
Tag:	His (3)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P73673

	RPE Protein, Mouse (HEK293, His) Ribulose-Phosphate 3-Epimerase; RPE; HUSSY-17	Mouse	HEK293
	RPE proteins play a key role in cellular metabolism by catalyzing the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. This enzyme activity is a key step in the non-oxidative phase of the pentose phosphate pathway and promotes the interconversion of pentose phosphates. RPE Protein, Mouse (HEK293, His) is the recombinant mouse-derived RPE protein, expressed by HEK293 , with C-His labeled tag. The total length of RPE Protein, Mouse (HEK293, His) is 228 a.a., with molecular weight of ~27 kDa.

HY-P74592

	RPE Protein, Human (HEK293, His) Ribulose-Phosphate 3-Epimerase; RPE; HUSSY-17	Human	HEK293
	The RPE Protein is responsible for catalyzing the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. RPE Protein, Human (HEK293, His) is the recombinant human-derived RPE protein, expressed by HEK293 , with C-His labeled tag. The total length of RPE Protein, Human (HEK293, His) is 228 a.a., with molecular weight of ~26.4 kDa.

HY-P71264

	RPE Protein, Human (His) Ribulose-Phosphate 3-Epimerase; Ribulose-5-Phosphate-3-Epimerase; RPE; HUSSY-17	Human	E. coli
	The RPE Protein, an enzyme, plays a crucial role in the metabolism of vitamin A. It converts retinol to retinaldehyde, which is essential for vision. In addition, RPE Protein inhibits tumor growth and may have potential therapeutic applications in treating certain conditions. RPE Protein, Human (His) is the recombinant human-derived RPE protein, expressed by E. coli , with C-6*His labeled tag. The total length of RPE Protein, Human (His) is 228 a.a., with molecular weight of ~28.0 kDa.


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Cat. No.	Product Name	Application	Reactivity

HY-P83565

RPE65 Antibody (YA3310)

LCA2; mRPE65; p63; rd12; Retinal pigment epithelium specific 61 kDa protein; RP20; RPE65; sRPE65
WB, IP Human, Mouse, Rat

Cat. No.	Product Name		Classification

HY-151872

HDAC-IN-48		Alkynes
HDAC-IN-48 is a potent HDAC inhibitor. HDAC-IN-48 is a hybrid molecule with great cytotoxic profile (GI₅₀~20 nM). HDAC-IN-48 consists of harmacophores of SAHA and CETZOLE molecules. HDAC-IN-48 induces ferroptosis and inhibits HDAC proteins . HDAC-IN-48 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Inhibitors & Agonists

Fluorescent Dye

Peptides

Natural
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Recombinant Proteins

Antibodies

Click Chemistry

RPE

Inhibitors & Agonists

Fluorescent Dye

Peptides

NaturalProducts

Recombinant Proteins

Antibodies

Click Chemistry

Natural
Products