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WS3 

Cat. No.: HY-12462 Purity: 98.26%
Handling Instructions

WS3 is a novel proliferative molecule that promotes pancreatic β cell proliferation in rodent and human primary islets. WS3 can be used for the research of type 1 diabetes.

For research use only. We do not sell to patients.

WS3 Chemical Structure

WS3 Chemical Structure

CAS No. : 1421227-52-2

Size Price Stock Quantity
10 mg USD 90 In-stock
Estimated Time of Arrival: December 31
50 mg USD 330 In-stock
Estimated Time of Arrival: December 31
100 mg USD 550 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Description

WS3 is a novel proliferative molecule that promotes pancreatic β cell proliferation in rodent and human primary islets. WS3 can be used for the research of type 1 diabetes[1].

IC50 & Target

IC50: 0.28 μM (β cell proliferation)[1]

In Vitro

WS3 induces pancreatic R7T1 β cell proliferation in dose response, with an EC50 value of 0.28 μM[1].
WS3 (1.0 nM-1.0 µM) reversibly proliferate primary retinal pigment epithelial (RPE) cells isolated from fetal and adult human donors. Following withdrawal of WS3, RPE cells differentiate into a functional monolayer, as exhibited by their expression of mature RPE genes and phagocytosis of photoreceptor outer segments[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

569.58

Formula

C₂₈H₃₀F₃N₇O₃

CAS No.
SMILES

O=C(C1CC1)NC2=NC=NC(OC3=CC=C(NC(NC4=CC=C(CN5CCN(C)CC5)C(C(F)(F)F)=C4)=O)C=C3)=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 2.2 mg/mL (3.86 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7557 mL 8.7784 mL 17.5568 mL
5 mM --- --- ---
10 mM --- --- ---
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

WS3WS 3WS-3Othersβ celldiabeteproliferationinsulinRPER7T1pancreaticretinalpigmentepithelialInhibitorinhibitorinhibit

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WS3
Cat. No.:
HY-12462
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