Pyridinium bisretinoid A2E TFA
Based on 1 Customer Validation
Pyridinium bisretinoid A2E (A2E) TFA is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E TFA is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E TFA mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E TFA can be used in the study of retinal degenerative diseases.
For research use only. We do not sell to patients.
- Purity: 90.0%
- CAS No.: 1821308-73-9
- Formula: C44H58F3NO3
- Molecular Weight:705.93
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Exposure of Pyridinium bisretinoid A2E (A2E) to light triggers its conversion into at least two products. One of these is epoxy-A2E, which is hydrophilic and can be transferred from the membrane to an aqueous solution. The other product is an unidentified hydrophobic substance[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1821308-73-9
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Appearance Solid
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Molecular Weight 705.93
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Formula C44H58F3NO3
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Color Brown to red
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SMILES
OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C.O=C([O-])C(F)(F)F
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Synonyms
A2E TFA; N-retinylidene-N-retinylethanolamine TFA
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 100 mg/mL (141.66 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (269 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555. [Content Brief]
[3]. Sokolov VS, et al. Interaction of pyridinium bis-retinoid (A2E) with bilayer lipid membranes. J Photochem Photobiol B. 2007 Feb 1;86(2):177-85. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.4166 mL | 7.0829 mL | 14.1657 mL | 35.4143 mL |
| 5 mM | 0.2833 mL | 1.4166 mL | 2.8331 mL | 7.0829 mL | |
| 10 mM | 0.1417 mL | 0.7083 mL | 1.4166 mL | 3.5414 mL | |
| 15 mM | 0.0944 mL | 0.4722 mL | 0.9444 mL | 2.3610 mL | |
| 20 mM | 0.0708 mL | 0.3541 mL | 0.7083 mL | 1.7707 mL | |
| 25 mM | 0.0567 mL | 0.2833 mL | 0.5666 mL | 1.4166 mL | |
| 30 mM | 0.0472 mL | 0.2361 mL | 0.4722 mL | 1.1805 mL | |
| 40 mM | 0.0354 mL | 0.1771 mL | 0.3541 mL | 0.8854 mL | |
| 50 mM | 0.0283 mL | 0.1417 mL | 0.2833 mL | 0.7083 mL | |
| 60 mM | 0.0236 mL | 0.1180 mL | 0.2361 mL | 0.5902 mL | |
| 80 mM | 0.0177 mL | 0.0885 mL | 0.1771 mL | 0.4427 mL | |
| 100 mM | 0.0142 mL | 0.0708 mL | 0.1417 mL | 0.3541 mL |
Pyridinium bisretinoid A2E TFA Related Classifications
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