Pyridinium bisretinoid A2E
Pyridinium bisretinoid A2E (A2E) is a fluorophore that can be isolated from lipofuscin in the retinal pigment epithelium (RPE). Pyridinium bisretinoid A2E is an initiator of blue-light-induced apoptosis. Photoactivation of Pyridinium bisretinoid A2E mediates autophagy and the production of reactive oxygen species. Pyridinium bisretinoid A2E can be used in the study of retinal degenerative diseases.
For research use only. We do not sell to patients.
- CAS No.: 173449-96-2
- Formula: C42H58NO+
- Molecular Weight:592.92
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Exposure of Pyridinium bisretinoid A2E (A2E) to light triggers its conversion into at least two products. One of these is epoxy-A2E, which is hydrophilic and can be transferred from the membrane to an aqueous solution. The other product is an unidentified hydrophobic substance[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 173449-96-2
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Molecular Weight 592.92
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Formula C42H58NO+
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SMILES
OCC[N+]1=CC=C(/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)C=C1/C=C(C)/C=C/C=C(C)/C=C/C3=C(C)CCCC3(C)C
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Synonyms
A2E
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
DMSO : 150 mg/mL (252.99 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
References
[1]. Jeong SY, et al. Photoactivation of N-retinylidene-N-retinylethanolamine compromises autophagy in retinal pigmented epithelial cells. Food Chem Toxicol. 2019 Sep;131:110555. [Content Brief]
[3]. Sokolov VS, et al. Interaction of pyridinium bis-retinoid (A2E) with bilayer lipid membranes. J Photochem Photobiol B. 2007 Feb 1;86(2):177-85. [Content Brief]
Complete Stock Solution Preparation Table
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.6866 mL | 8.4328 mL | 16.8657 mL | 42.1642 mL |
| 5 mM | 0.3373 mL | 1.6866 mL | 3.3731 mL | 8.4328 mL | |
| 10 mM | 0.1687 mL | 0.8433 mL | 1.6866 mL | 4.2164 mL | |
| 15 mM | 0.1124 mL | 0.5622 mL | 1.1244 mL | 2.8109 mL | |
| 20 mM | 0.0843 mL | 0.4216 mL | 0.8433 mL | 2.1082 mL | |
| 25 mM | 0.0675 mL | 0.3373 mL | 0.6746 mL | 1.6866 mL | |
| 30 mM | 0.0562 mL | 0.2811 mL | 0.5622 mL | 1.4055 mL | |
| 40 mM | 0.0422 mL | 0.2108 mL | 0.4216 mL | 1.0541 mL | |
| 50 mM | 0.0337 mL | 0.1687 mL | 0.3373 mL | 0.8433 mL | |
| 60 mM | 0.0281 mL | 0.1405 mL | 0.2811 mL | 0.7027 mL | |
| 80 mM | 0.0211 mL | 0.1054 mL | 0.2108 mL | 0.5271 mL | |
| 100 mM | 0.0169 mL | 0.0843 mL | 0.1687 mL | 0.4216 mL |
Pyridinium bisretinoid A2E Related Classifications
HY-134928 Related Classifications
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