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Referencia número: HY-155762

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Anti-neuroinflammation agent 1

Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype.

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No. CAS: 2968412-77-1
Fòrmula: C₂₂H₂₀ClF₆N₃O₃
Peso molecular:523.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Anti-neuroinflammation agent 1 Chemical Structure

No. CAS: 2968412-77-1

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Descripciòn

Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype^[1].

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In Vitro

Anti-neuroinflammation agent 1 (BMP 29) shows more potent anti-neuroinflammatory activity and no toxicity to BV2 microglia cells in vitro. Anti-neuroinflammation agent 1 significantly reduces the number of M1 phenotype of microglia cells, but significantly increases the number of M2 phenotype of microglia cells in lipopolysaccharide (LPS)-induced BV2 microglia cells. Anti-neuroinflammation agent 1 significantly reduces the secretion of inflammatory cytokines (IL-18, IL-1β, TNF-α), but increases the secretion of anti-inflammatory cytokines (IL-10) from LPS-induced BV2 microglia cells. Also, Anti-neuroinflammation agent 1 inhibits the NOD-like receptor NLRP3 inflammasome formation, and down-regulated the expression of M2 isoform of pyruvate kinase in LPS-induced BV2 microglia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice, Anti-neuroinflammation agent 1 (BMP 29) reduces the neuroinflammation in cuprizone-induced inflammatory and demyelinating mice by reducing the expression of inducible nitric-oxide synthase, but increased the expression of CD206^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

No. CAS 2968412-77-1
Peso molecular 523.86
Fòrmula C₂₂H₂₀ClF₆N₃O₃
SMILES

COC1=CC2=C(C(OC)=C1)C3=C(CCO2)C(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)N=C(N)N3.Cl
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

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Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Yang Yang, et al. Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization. Eur J Med Chem. 2023 Jul 27;259:115688. [Content Brief]

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Anti-neuroinflammation agent 1

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Anti-neuroinflammation agent 1

Ver todos los productos específicos de isoformas NOD-like Receptor (NLR)

Ver todos los productos específicos de isoformas Interleukin Related

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