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Cat. No.: HY-155762

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Anti-neuroinflammation agent 1

Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype.

For research use only. We do not sell to patients.

CAS No.: 2968412-77-1
Formula: C₂₂H₂₀ClF₆N₃O₃
Molecular Weight:523.86

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

Anti-neuroinflammation agent 1 Chemical Structure

CAS No.: 2968412-77-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
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Biological Activity

Description

Anti-neuroinflammation agent 1 is a potent anti-neuroinflammation agent that regulates polarization BV2 microglia cells from M1 phenotype to M2 phenotype^[1].

All NOD-like Receptor (NLR) Isoforms :

All Interleukin Related Isoforms :

In Vitro

Anti-neuroinflammation agent 1 (BMP 29) shows more potent anti-neuroinflammatory activity and no toxicity to BV2 microglia cells in vitro. Anti-neuroinflammation agent 1 significantly reduces the number of M1 phenotype of microglia cells, but significantly increases the number of M2 phenotype of microglia cells in lipopolysaccharide (LPS)-induced BV2 microglia cells. Anti-neuroinflammation agent 1 significantly reduces the secretion of inflammatory cytokines (IL-18, IL-1β, TNF-α), but increases the secretion of anti-inflammatory cytokines (IL-10) from LPS-induced BV2 microglia cells. Also, Anti-neuroinflammation agent 1 inhibits the NOD-like receptor NLRP3 inflammasome formation, and down-regulated the expression of M2 isoform of pyruvate kinase in LPS-induced BV2 microglia cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

In mice, Anti-neuroinflammation agent 1 (BMP 29) reduces the neuroinflammation in cuprizone-induced inflammatory and demyelinating mice by reducing the expression of inducible nitric-oxide synthase, but increased the expression of CD206^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2968412-77-1
Molecular Weight 523.86
Formula C₂₂H₂₀ClF₆N₃O₃
SMILES

COC1=CC2=C(C(OC)=C1)C3=C(CCO2)C(C4=CC(C(F)(F)F)=CC(C(F)(F)F)=C4)N=C(N)N3.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Yang Yang, et al. Discovery of anti-neuroinflammatory agents from 1,4,5,6-tetrahydrobenzo[2,3]oxepino[4,5-d]pyrimidin-2-amine derivatives by regulating microglia polarization. Eur J Med Chem. 2023 Jul 27;259:115688. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References

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Anti-neuroinflammation agent 1

All NOD-like Receptor (NLR) Isoforms

All Interleukin Related Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Anti-neuroinflammation agent 1 Related Classifications

HY-155762 Related Classifications