1. Metabolic Enzyme/Protease
    GPCR/G Protein
    Epigenetics
    Cell Cycle/DNA Damage
    Apoptosis
    Immunology/Inflammation
  2. Endogenous Metabolite
    Phosphodiesterase (PDE)
    Adenosine Receptor
    HDAC
    Apoptosis
    Interleukin Related
    TNF Receptor
  3. Theophylline sodium acetate

Theophylline sodium acetate  (Synonyms: 1,3-Dimethylxanthine sodium acetate; Theo-24 sodium acetate)

Cat. No.: HY-B0809B
Handling Instructions

Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

For research use only. We do not sell to patients.

Theophylline sodium acetate Chemical Structure

Theophylline sodium acetate Chemical Structure

CAS No. : 8002-89-9

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Description

Theophylline (1,3-Dimethylxanthine) sodium acetate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) sodium acetate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) sodium acetate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) sodium acetate induces apoptosis. Theophylline (1,3-Dimethylxanthine) sodium acetate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Theophylline (1,3-Dimethylxanthine) sodium acetate (1-1000 µM) inhibits cAMP hydrolysis by PDE in homogenates of bronchial tissue to relax human bronchus and pulmonary arteries[1].
Theophylline (1,3-Dimethylxanthine) sodium acetate (10 µg/mL; 24 h; eosinophils) induces apoptosis through a reduction in the antiapoptotic protein Bcl-2[2].
Theophylline (1,3-Dimethylxanthine) sodium acetate (0-500 µM; 2 h; A549 cells) inhibits NF-κB activation, I kappa B alpha (I-κBα) degradation and decreases the level of IL-6 in a concentration-dependent manner[3].
Theophylline (1,3-Dimethylxanthine) sodium acetate (0-1000 µM; 30 min; A549 cells) induces histone deacetylase activity to decrease inflammatory gene expression[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: A549 cells
Concentration: 0, 20, 100 and 500 µM
Incubation Time: 2 hours
Result: Decreased the expression of NF-κB p65 and I-κBα degradation in a concentration-dependent manner.

Western Blot Analysis[2]

Cell Line: Eosinophils
Concentration: 10 µg/mL
Incubation Time: 24 hours
Result: Decreased the expression of Bcl-2.
In Vivo

Theophylline (1,3-Dimethylxanthine) (100 mg/kg; i.p.; daily, for 9 d; male Swiss mice) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; daily, for 9 days
Result: Increased IL-6 and IL-10 levels and inhibited TNF-α and NO.
Clinical Trial
Molecular Weight

284.18

Formula

C9H10N4Na2O4

CAS No.
SMILES

CC(O[Na])=O.O=C(N1C)N(C)C2=C([N-]C=N2)C1=O.[Na+]

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Theophylline sodium acetate
Cat. No.:
HY-B0809B
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