2. Theophylline monohydrate

Theophylline monohydrate  (Synonyms: 1,3-Dimethylxanthine monohydrate; Theo-24 monohydrate)

Cat. No.: HY-B0809A
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Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

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Theophylline monohydrate Chemical Structure

Theophylline monohydrate Chemical Structure

CAS No. : 5967-84-0

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Other Forms of Theophylline monohydrate:

Theophylline monohydrate Related Antibodies

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Description

Theophylline (1,3-Dimethylxanthine) monohydrate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline (1,3-Dimethylxanthine) monohydrate inhibits PDE3 activity to relax airway smooth muscle. Theophylline (1,3-Dimethylxanthine) monohydrate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline (1,3-Dimethylxanthine) monohydrate induces apoptosis. Theophylline (1,3-Dimethylxanthine) monohydrate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

In Vitro

Theophylline (1,3-Dimethylxanthine) monohydrate (1-1000 µM) inhibits cAMP hydrolysis by PDE in homogenates of bronchial tissue to relax human bronchus and pulmonary arteries[1].
Theophylline (1,3-Dimethylxanthine) monohydrate (10 µg/mL; 24 h; eosinophils) induces apoptosis through a reduction in the antiapoptotic protein Bcl-2[2].
Theophylline (1,3-Dimethylxanthine) monohydrate (0-500 µM; 2 h; A549 cells) inhibits NF-κB activation, I kappa B alpha (I-κBα) degradation and decreases the level of IL-6 in a concentration-dependent manner[3].
Theophylline (1,3-Dimethylxanthine) monohydrate (0-1000 µM; 30 min; A549 cells) induces histone deacetylase activity to decrease inflammatory gene expression[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Theophylline monohydrate Related Antibodies

Western Blot Analysis[3]

Cell Line: A549 cells
Concentration: 0, 20, 100 and 500 µM
Incubation Time: 2 hours
Result: Decreased the expression of NF-κB p65 and I-κBα degradation in a concentration-dependent manner.

Western Blot Analysis[2]

Cell Line: Eosinophils
Concentration: 10 µg/mL
Incubation Time: 24 hours
Result: Decreased the expression of Bcl-2.
In Vivo

Theophylline (1,3-Dimethylxanthine) (100 mg/kg; i.p.; daily, for 9 d; male Swiss mice) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; daily, for 9 days
Result: Increased IL-6 and IL-10 levels and inhibited TNF-α and NO.
Clinical Trial
Molecular Weight

198.18

Formula

C7H10N4O3
CAS No.
SMILES

O=C1C2=C(N(C)C(N1C)=O)N=CN2.O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Theophylline5967-84-01,3-DimethylxanthineTheo-24Theo24Theo 24Inhibitorinhibitorinhibit

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