1. Anti-infection
    Metabolic Enzyme/Protease
  2. Influenza Virus
    Endogenous Metabolite
  3. Theaflavin

Theaflavin 

Cat. No.: HY-N0243 Purity: 99.69%
Handling Instructions

Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

For research use only. We do not sell to patients.

Theaflavin Chemical Structure

Theaflavin Chemical Structure

CAS No. : 4670-05-7

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 186 In-stock
Estimated Time of Arrival: December 31
2 mg USD 80 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 450 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

Theaflavin is a suitable natural inhibitor against influenza A (H1N1) neuraminidase.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Theaflavin, found in green tea, is observed to inhibit H1N1 NA proteins strongly supported by lowest docking energy. Theaflavin is a plant product traditionally used for treatment of influenza infection. Green tea is particularly rich in polyphenolic compounds like Theaflavin. Theaflavin derivatives have shown pronounced antiviral activity. Theaflavin is found to interact with the amino acid residues like Arg118, Asp151, Asp 152, Arg193, Asp199, Asn344, and Arg430 of NA by forming hydrogen bonds[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

564.49

Formula

C₂₉H₂₄O₁₂

CAS No.

4670-05-7

SMILES

O=C1C(O)=CC([[email protected]@H]2[[email protected]](O)CC3=C(O)C=C(O)C=C3O2)=CC4=C([[email protected]@H]5[[email protected]](O)CC6=C(O)C=C(O)C=C6O5)C=C(O)C(O)=C41

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (221.44 mM; Need ultrasonic)

H2O : 2 mg/mL (3.54 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7715 mL 8.8576 mL 17.7151 mL
5 mM 0.3543 mL 1.7715 mL 3.5430 mL
10 mM 0.1772 mL 0.8858 mL 1.7715 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 6.25 mg/mL (11.07 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 6.25 mg/mL (11.07 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.69%

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Keywords:

TheaflavinInfluenza VirusEndogenous MetaboliteInhibitorinhibitorinhibit

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Theaflavin
Cat. No.:
HY-N0243
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