2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. Beauvericin

Beauvericin is a Fusarium mycotoxin. Beauvericin inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 3 μM in an enzyme assay using rat liver microsomes.

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Beauvericin Chemical Structure

Beauvericin Chemical Structure

CAS No. : 26048-05-5

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5 mg USD 190 In-stock
10 mg USD 304 In-stock
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Based on 1 publication(s) in Google Scholar

Beauvericin Related Antibodies

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ACAT1 ACAT2 MGAT2 ACAT

  • Biological Activity

  • Purity & Documentation

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Description

Beauvericin is a Fusarium mycotoxin. Beauvericin inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 3 μM in an enzyme assay using rat liver microsomes[1].

IC50 & Target

ACAT

 

Molecular Weight

783.95

Formula

C45H57N3O9
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CN([C@H](C(O[C@](C(N([C@H](C(O[C@@H]1C(C)C)=O)CC2=CC=CC=C2)C)=O)([H])C(C)C)=O)CC3=CC=CC=C3)C([C@H](OC([C@@H](N(C1=O)C)CC4=CC=CC=C4)=O)C(C)C)=O
Structure Classification
Initial Source

Fusarium proliferatum,F. semitectum, and F. subglutinans
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (127.56 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.2756 mL 6.3780 mL 12.7559 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.95%

COA (261 KB) HNMR (299 KB) LCMS (87 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.2756 mL 6.3780 mL 12.7559 mL 31.8898 mL
5 mM 0.2551 mL 1.2756 mL 2.5512 mL 6.3780 mL
10 mM 0.1276 mL 0.6378 mL 1.2756 mL 3.1890 mL
15 mM 0.0850 mL 0.4252 mL 0.8504 mL 2.1260 mL
20 mM 0.0638 mL 0.3189 mL 0.6378 mL 1.5945 mL
25 mM 0.0510 mL 0.2551 mL 0.5102 mL 1.2756 mL
30 mM 0.0425 mL 0.2126 mL 0.4252 mL 1.0630 mL
40 mM 0.0319 mL 0.1594 mL 0.3189 mL 0.7972 mL
50 mM 0.0255 mL 0.1276 mL 0.2551 mL 0.6378 mL
60 mM 0.0213 mL 0.1063 mL 0.2126 mL 0.5315 mL
80 mM 0.0159 mL 0.0797 mL 0.1594 mL 0.3986 mL
100 mM 0.0128 mL 0.0638 mL 0.1276 mL 0.3189 mL
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Beauvericin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Beauvericin26048-05-5AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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