1. Metabolic Enzyme/Protease
    GPCR/G Protein
    Apoptosis
  2. Farnesyl Transferase
    Ras
    Apoptosis
  3. Manumycin A

Manumycin A 

Cat. No.: HY-N6796
Handling Instructions

Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A induces apoptosis and exerts antitumor activity .

For research use only. We do not sell to patients.

Manumycin A Chemical Structure

Manumycin A Chemical Structure

CAS No. : 52665-74-4

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Description

Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A induces apoptosis and exerts antitumor activity[1] [2][3].

IC50 & Target

Farnesyltransferase, Ras[1]

Molecular Weight

550.64

Formula

C₃₁H₃₈N₂O₇

CAS No.

52665-74-4

SMILES

CCCC[[email protected]@H](C)/C=C(C)/C=C(C)/C(NC1=C[[email protected]](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[[email protected]]3([H])O[[email protected]]3([H])C1=O)=O

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Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Manumycin A
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