1. Metabolic Enzyme/Protease
    GPCR/G Protein
    Apoptosis
  2. Farnesyl Transferase
    Ras
    Apoptosis
    Phospholipase
  3. Manumycin A

Manumycin A 

Cat. No.: HY-N6796
Handling Instructions

Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A induces apoptosis and exerts antitumor activity . Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling. Manumycin A is a nSMase inhibitor (EC50=0.25 μM).

For research use only. We do not sell to patients.

Manumycin A Chemical Structure

Manumycin A Chemical Structure

CAS No. : 52665-74-4

Size Price Stock
5 mg USD 800 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All Ras Isoform Specific Products:

View All Phospholipase Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A induces apoptosis and exerts antitumor activity[1] [2][3]. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling[4]. Manumycin A is a nSMase inhibitor (EC50=0.25 μM)[5].

IC50 & Target

Farnesyltransferase, Ras, nSMase inhibitor[1][5]

Molecular Weight

550.64

Formula

C₃₁H₃₈N₂O₇

CAS No.

52665-74-4

SMILES

CCCC[[email protected]@H](C)/C=C(C)/C=C(C)/C(NC1=C[[email protected]](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[[email protected]]3([H])O[[email protected]]3([H])C1=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Manumycin AFarnesyl TransferaseRasApoptosisPhospholipaseFtaseInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Manumycin A
Cat. No.:
HY-N6796
Quantity:
MCE Japan Authorized Agent: