52665-74-4
Chemical Structure
Manumycin A
- CAS No.: 52665-74-4
- Formula:C31H38N2O7
- Molecular Weight:550.64
IUPAC Name: (R,2E,4E)-N-((1S,5S,6R)-5-hydroxy-5-((1E,3E,5E)-7-((2-hydroxy-5-oxocyclopent-1-en-1-yl)amino)-7-oxohepta-1,3,5-trien-1-yl)-2-oxo-7-oxabicyclo[4.1.0]hept-3-en-3-yl)-2,4,6-trimethyldeca-2,4-dienamide
InChIKey: TWWQHCKLTXDWBD-MVTGTTCWSA-N
SMILES: CCCC[C@@H](C)/C=C(C)/C=C(C)/C(NC1=C[C@](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[C@]3([H])O[C@]3([H])C1=O)=O
Biological Activity: Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion[1][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Manumycin A | 98.30% | Manumycin A is a polyketide antibiotic and an inhibitor of thioredoxin reductase 1 (TrxR-1). Manumycin A can inhibit the growth of breast cancer cells and exert its anti-tumor activity through LC3. Manumycin A can downregulate the release of pro-inflammatory cytokines in human monocytes stimulated by TNF α, and has potential anti-inflammatory activity. Manumycin A can inhibit the Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration resistant prostate cancer cells to suppress exosome biogenesis and secretion. | ||||||||||||||||||||
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- [1]. Cecrdlova E, et al. Manumycin A downregulates release of proinflammatory cytokines from TNF alpha stimulated human monocytes. Immunol Lett. 2016 Jan;169:8-14. [Content Brief]
- [3]. Singha PK, et al. Manumycin A inhibits triple-negative breast cancer growth through LC3-mediated cytoplasmic vacuolation death. Cell Death Dis. 2013 Jan 17;4(1):e457.
- [4]. Datta A, et al. Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling and hnRNP H1 in castration-resistant prostate cancer cells. Cancer Lett. 2017 Nov 1;408:73-81. [Content Brief]
Keywords
