1. GPCR/G Protein Neuronal Signaling
  2. Cannabinoid Receptor
  3. CB2R agonist 1

CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role.

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CB2R agonist 1 Chemical Structure

CB2R agonist 1 Chemical Structure

CAS No. : 1817633-49-0

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Description

CB2R agonist 1 is a selective ligand of cannabinoid receptor subtype 2 (CB2R) with an EC50 value of 0.56 µM. CB2R agonist 1 has high affinity and excellent selectivity for human CB2R and CB1R respectively. CB2R agonist 1 regulates the production of pro-inflammatory cytokines and anti-inflammatory cytokines and play an immunomodulatory role[1].

IC50 & Target[1]

CB2R

0.56 μM (EC50)

In Vitro

CB2R agonist 1 (Compound 4) (1 μM and 10 μM; 24 h) increases the production of IL-4 and IL-10 anti-inflammatory cytokines and reduces the production of TNF-α, IFN-γ, IL-1β and IL-6 pro-inflammatory cytokines in monocytes and macrophages with concentration-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

340.50

Formula

C22H32N2O

CAS No.
Unlabeled CAS

SMILES

O=C(C1=C(NCCCCC)C=CC=C1)NC23CC4CC(C3)CC(C2)C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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CB2R agonist 1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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CB2R agonist 1
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HY-152576
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