SIKs-IN-1
SIKs-IN-1 (compound 8h), a pyrimidine-5-carboxamide derivative, is a Salt-inducible kinases (SIKs) inhibitor. SIKs regulates the transformation of M1/M2 macrophages, involving in inflammation process. SIKs-IN-1 inhibits SIK activity, up-regulates anti-inflammatory cytokine IL-10, but down-regulates pro-inflammatory cytokine IL-12. SIKs-IN-1 shows excellent anti-inflammatory effects in a DSS-induced colitis model.
For research use only. We do not sell to patients.
- CAS No.: 2927557-06-8
- Formula: C27H31F2N7O
- Molecular Weight:507.58
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 2927557-06-8
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Molecular Weight 507.58
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Formula C27H31F2N7O
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SMILES
O=C(NC1=C(F)C=CC=C1C)C2=C(NC3CCC3)N=C(NC4=CC=C(N5CCN(C)CC5)C(F)=C4)N=C2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
SIKs-IN-1 Related Classifications
HY-149365 Related Classifications
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