1. Apoptosis
  2. TNF Receptor
  3. (Rac)-Benpyrine

(Rac)-Benpyrine 

Cat. No.: HY-133807A Purity: 99.30%
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(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research.

For research use only. We do not sell to patients.

(Rac)-Benpyrine Chemical Structure

(Rac)-Benpyrine Chemical Structure

CAS No. : 1333714-43-4

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10 mM * 1 mL in DMSO USD 198 In-stock
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100 mg USD 1200 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of (Rac)-Benpyrine:

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Description

(Rac)-Benpyrine, a racemate of Benpyrine, is a potent and orally active TNF-α inhibitor. (Rac)-Benpyrine has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].

IC50 & Target[1]

TNF-α

 

In Vitro

(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1]
Dosage: 25 mg/kg, 50 mg/kg
Administration: Oral gavage; daily; for 3 weeks
Result: The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
Molecular Weight

308.34

Formula

C₁₆H₁₆N₆O

CAS No.

1333714-43-4

SMILES

O=C1N(CC2=CC=CC=C2)CC(NC3=C4N=CNC4=NC=N3)C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (40.54 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2432 mL 16.2159 mL 32.4317 mL
5 mM 0.6486 mL 3.2432 mL 6.4863 mL
10 mM 0.3243 mL 1.6216 mL 3.2432 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.25 mg/mL (4.05 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.25 mg/mL (4.05 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.25 mg/mL (4.05 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(Rac)-BenpyrineTNF ReceptorTumor Necrosis Factor ReceptorTNFRTNF-αNF-κBautoimmuneanti-inflammatoryIFN-γIL-1βIL-6IL-10Inhibitorinhibitorinhibit

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(Rac)-Benpyrine
Cat. No.:
HY-133807A
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