1. Apoptosis
  2. TNF Receptor
  3. (Rac)-Benpyrine

(Rac)-Benpyrine 

Cat. No.: HY-133807A
Handling Instructions

(Rac)-Benpyrine is a racemate of Benpyrine. (Rac)-Benpyrine is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research.

For research use only. We do not sell to patients.

(Rac)-Benpyrine Chemical Structure

(Rac)-Benpyrine Chemical Structure

CAS No. : 1333714-43-4

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Description

(Rac)-Benpyrine is a racemate of Benpyrine. (Rac)-Benpyrine is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research[1].

IC50 & Target[1]

TNF-α

 

In Vitro

(Rac)-Benpyrine (Compound 001; 5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages[1].

In Vivo

(Rac)-Benpyrine (Compound 001; 25-50 mg/kg; oral gavage; daily; for 3 weeks; Kunming mice) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down, and the weight index increase caused by the arthritis also has no obvious reduction[1].

Animal Model: Kunming mice (7-8 weeks) treated with bovine type II collagen and a CFA complete adjuvant[1]
Dosage: 25 mg/kg, 50 mg/kg
Administration: Oral gavage; daily; for 3 weeks
Result: The inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum were obviously reduced, and the anti-inflammatory factor IL-10 was obviously increased.
Molecular Weight

308.34

Formula

C₁₆H₁₆N₆O

CAS No.

1333714-43-4

SMILES

O=C1N(CC2=CC=CC=C2)CC(NC3=C4N=CNC4=NC=N3)C1

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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

(Rac)-BenpyrineTNF ReceptorTumor Necrosis Factor ReceptorTNFRTNF-αNF-κBautoimmuneanti-inflammatoryIFN-γIL-1βIL-6IL-10Inhibitorinhibitorinhibit

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(Rac)-Benpyrine
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HY-133807A
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