1. GPCR/G Protein Epigenetics Cell Cycle/DNA Damage Apoptosis Immunology/Inflammation
  2. Adenosine Receptor HDAC Apoptosis Interleukin Related TNF Receptor
  3. Theophylline sodium glycinate

Theophylline sodium glycinate  (Synonyms: 1,3-Dimethylxanthine sodium glycinate; Theo-24 sodium glycinate)

Cat. No.: HY-107909
Handling Instructions

Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research.

For research use only. We do not sell to patients.

Theophylline sodium glycinate Chemical Structure

Theophylline sodium glycinate Chemical Structure

CAS No. : 8000-10-0

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Description

Theophylline (1,3-Dimethylxanthine) sodium glycinate is a potent phosphodiesterase (PDE) inhibitor, adenosine receptor antagonist, and histone deacetylase (HDAC) activator. Theophylline sodium glycinate inhibits PDE3 activity to relax airway smooth muscle. Theophylline sodium glycinate has anti-inflammatory activity by increase IL-10 and inhibit NF-κB into the nucleus. Theophylline sodium glycinate induces apoptosis. Theophylline sodium glycinate can be used for asthma and chronic obstructive pulmonary disease (COPD) research[1][2][3][4][5].

In Vitro

Theophylline sodium glycinate (1-1000 µM) inhibits cAMP hydrolysis by PDE in homogenates of bronchial tissue to relax human bronchus and pulmonary arteries[1].
Theophylline sodium glycinate (10 µg/mL; 24 h) induces apoptosis through a reduction in the antiapoptotic protein Bcl-2 in eosinophils[2].
Theophylline sodium glycinate (0-500 µM; 2 h) inhibits NF-κB activation, I kappa B alpha (I-κBα) degradation and decreases the level of IL-6 in a concentration-dependent manner[3].
Theophylline sodium glycinate (0-1000 µM; 30 min; A549 cells) induces histone deacetylase activity to decrease inflammatory gene expression[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[3]

Cell Line: A549 cells
Concentration: 0, 20, 100 and 500 µM
Incubation Time: 2 hours
Result: Decreased the expression of NF-κB p65 and I-κBα degradation in a dose-dependent manner.
In Vivo

Theophylline sodium glycinate (100 mg/kg; i.p.; daily, for 9 d) has anti-inflammatory activity in mice and increases IL-6 and IL-10 levels and inhibits TNF-α and NO in male Swiss mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss mice[1]
Dosage: 100 mg/kg
Administration: Intraperitoneal injection; daily; for 9 days
Result: Increased IL-6 and IL-10 levels and inhibited TNF-α and NO.
Clinical Trial
Molecular Weight

278.22

Formula

C9H13N5NaO4+

CAS No.
SMILES

NCC(O)=O.O=C(N1C)C2=C(NC=N2)N(C)C1=O.[Na+]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Theophylline sodium glycinate
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HY-107909
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