1. Cell Cycle/DNA Damage
    Immunology/Inflammation
  2. CDK
    Interleukin Related
  3. BRD6989

BRD6989 

Cat. No.: HY-122586
Handling Instructions

BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes.

For research use only. We do not sell to patients.

BRD6989 Chemical Structure

BRD6989 Chemical Structure

CAS No. : 642008-81-9

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Description

BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes[1].

IC50 & Target[1]

CDK8

~200 nM (IC50)

recombinant CDK8

~0.5 μM (IC50)

recombinant CDK19

>30 μM (IC50)

IL-10

 

In Vitro

Pretreatment of BMDCs with BRD6989 (0-100 μM; for 48 hours) increases IL-10 production with an EC50 of ~1 μM[1].
BRD6989 (0.6, 1.7, 5, 15 μM) suppresses phosphorylation of the STAT1 transactivation domain at Ser727 in IFNγ-stimulated BMDCs[1].
BRD6989 (5 µM; ~2 hours) suppresses induction of STAT1–STAT2 activity and NF-κB activation to a varying degree after stimulation of BMDMs[1].
BRD6989 (5 µM; 24 hours) enhances IL-10 production in activated human and murine macrophages and dendritic cells[1].

Molecular Weight

264.33

Formula

C₁₆H₁₆N₄

CAS No.

642008-81-9

SMILES

N#CC1=C(C2=CC=CN=C2)C3=C(N=C1N)CCC(C)C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

BRD6989BRD 6989BRD-6989CDKInterleukin RelatedCyclin dependent kinaseILcortistatin-ACDK8IL-10CDK19BMDCsinflammatoryInhibitorinhibitorinhibit

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BRD6989
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