642008-81-9
642008-81-9
Chemical Structure
BRD6989
- CAS No.: 642008-81-9
- Formula:C16H16N4
- Molecular Weight:264.33
IUPAC Name: 2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
InChIKey: QSYBDNXNOJIKML-UHFFFAOYSA-N
SMILES: N#CC1=C(C2=CC=CN=C2)C3=C(N=C1N)CCC(C)C3
Biological Activity: BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BRD6989 | 99.54% | BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.74
HY-W027126Hepatoprotective agent-2 -
Similarity Score 0.74
HY-169541CDK8-IN-18 -
Similarity Score 0.61
HY-162137Hepatoprotective agent-1 -
Similarity Score 0.59
HY-147545A1AR antagonist 6 -
Similarity Score 0.54
HY-W674276WAY-325485 -
Similarity Score 0.53
HY-156915Pim-1 kinase inhibitor 13 -
Similarity Score 0.52
HY-147981Tubulin polymerization-IN-31 -
Similarity Score 0.51
HY-187161IL-4-IN-3 -
Similarity Score 0.51
HY-W0493127-Methoxytacrine -
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