642008-81-9
642008-81-9
Chemical Structure
BRD6989
- CAS No.: 642008-81-9
- Formula:C16H16N4
- Molecular Weight:264.33
IUPAC Name: 2-amino-6-methyl-4-(pyridin-3-yl)-5,6,7,8-tetrahydroquinoline-3-carbonitrile
InChIKey: QSYBDNXNOJIKML-UHFFFAOYSA-N
SMILES: N#CC1=C(C2=CC=CN=C2)C3=C(N=C1N)CCC(C)C3
Biological Activity: BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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BRD6989 | 99.54% | BRD6989, an analog of the natural product cortistatin A (dCA), inhibits CDK8 and upregulates IL-10. BRD6989 selectively binds a complex of CDK8 with an IC50 of ~200 nM. BRD6989 inhibits the kinase activity of recombinant CDK8 or CDK19 complexes. | ||||||||||||||||||||
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References
Keywords
