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Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5(IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .
IL5 Human Pre-designed siRNA Set A contains three designed siRNAs for IL5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Il5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Il5 Rat Pre-designed siRNA Set A contains three designed siRNAs for Il5 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
IL5RA Human Pre-designed siRNA Set A contains three designed siRNAs for IL5RA gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
YM-90709 is a novel IL-5 inhibitor which selectively blocks the binding of IL-5 to the IL-5 receptor (IL-5R).YM-90709 potently inhibits the binding of [ 125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0 and 0.57 μM .
SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation .
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5(IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with KD values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5(IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .
Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC50 of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .
Lyn peptide inhibitor is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor can be used for study of asthma, allergic, and other eosinophilic disorders .
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .
Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .
Suplatast Tosilate (IPD 1151T) is an orally active Th2 cytokine inhibitor which can inhibit both IL-4 and IL-5 production from Th2 cells and suppress IgE synthesis. Suplatast Tosilate is an anti-allergic agent. Suplatast Tosilate has antiasthmatic, anti-inflammatory and antifibrotic activity .
IMMH001, also called SYL930, is an orally active, potent and selective S1P1 (sphingosine-1-phosphate receptor 1) agonist. IMMH001 decreased levels of both chemokines and proinflammatory cytokines, including IL-1β, IL-5, IL-18, IP10, CCL3, and CCL5. IMMH001 can be used for rheumatoid arthritis (RA) research .
Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma .
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .
Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects .
Lyn peptide inhibitor TFA is a potent and cell-permeable inhibitor of Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. Lyn peptide inhibitor TFA blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to βc subunit of IL-3/GM-CSF/IL-5 receptors. Lyn peptide inhibitor TFA can be used for study of asthma, allergic, and other eosinophilic disorders .
Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5(IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .
Reslizumab (Sch 55700) is humanized monoclonal antibodies that target interleukin-5(IL-5) for the treatment of eosinophilic asthma. Reslizumab is effective in neutralizing the function of IL-5. Reslizumab has high binding affinity for human IL-5, with KD values of 109 pM and 4.3 pM in the the Biacore surface plasmon resonance and Kinetic Exclusion Assay, respectively .
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5(IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma .
Trabikibart (CSL311), a βc-specific, fully human monoclonal antibody, binds to a unique epitope that is specific to the cytokine-binding site of the human βc receptor. Trabikibart has picomolar binding affinity for the human βc receptor. Trabikibart is a potent inhibitor of the combined effects of IL-3, GM-CSF and IL-5 on the survival of eosinophils. Trabikibart has the potential for chronic inflammatory diseases research .
Benralizumab (anti-IL5RA ) (MEDI-563 (anti-IL5RA ); BIW-8405 (anti-IL5RA )) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma study .
Benralizumab (MEDI-563) is an interleukin-5 receptor α (IL-5Rα)-directed cytolytic monoclonal antibody that induces direct, rapid and nearly complete depletion of eosinophils via enhanced antibody-dependent cell-mediated cytotoxicity. Benralizumab can be used for severe eosinophilic asthma .
Lirentelimab (AK002) is a humanized IgG1 monoclonal antibody that targets sialic acid-binding Ig-like lectin 8 (SIGLEC8). Lirentelimab induces cell apoptosis of IL-5-activated eosinophils and inhibits IgE-mediated mast cell activation. Lirentelimab can be used for the research of eosinophilic gastritis and duodenitis .
Luteolin-4'-O-glucoside is an IL-5 inhibitor with an IC50 of 3.7 μM. Luteolin-4'-O-glucoside resists hyperuricemia and acute gouty arthritis activity. Luteolin-4'-O-glucoside shows anticancer activity .
Eckol is a potent hMAO-A (Mixed) and hMAO-B (non-competitive) inhibitor with IC50s of 7.20 and 83.44 μM, respectively. Eckol shows stimulatory effects in maize and can be used as a plant biostimulant. Eckol also shows antiallergic and antiviral effects .
The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. Animal-Free IL-5 Protein, Human (His) is the recombinant human-derived animal-FreeIL-5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-5 Protein, Human (His) is 115 a.a., with molecular weight of ~14.09 kDa.
IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis. In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells. Animal-Free IL-5 Protein, Mouse (His) is the recombinant mouse-derived animal-FreeIL-5 protein, expressed by E. coli , with C-His labeled tag. The total length of Animal-Free IL-5 Protein, Mouse (His) is 113 a.a., with molecular weight of ~13.93 kDa.
The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (HEK293, His) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with C-His labeled tag. The total length of IL-5 Protein, Human (HEK293, His) is 115 a.a., with molecular weight of ~20.0 kDa.
IL-5 Protein, expressed by T-lymphocytes and NK cells, is vital for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production and growth. IL-5 Protein activates kinases LYN, SYK, and JAK2 through IL5RA and CSF2RB subunits, signaling via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Pig (His) is the recombinant pig-derived IL-5 protein, expressed by E. coli , with N-His labeled tag. The total length of IL-5 Protein, Pig (His) is 113 a.a., with molecular weight of ~17.0 kDa.
IL-5 protein is expressed by T lymphocytes and NK cells and plays a crucial role in eosinophil survival, differentiation, and chemotaxis. It also promotes immunoglobulin production, growth and differentiation in B cells. IL-5 Protein, Canine (sf9, His) is the recombinant canine-derived IL-5 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of IL-5 Protein, Canine (sf9, His) is 134 a.a., with molecular weight of 17-19 kDa.
IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis. In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells. IL-5 Protein, Mouse (sf9, His) is the recombinant mouse-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of IL-5 Protein, Mouse (sf9, His) is 133 a.a., with molecular weight of ~18 kDa.
IL-5 Protein, produced by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It stimulates immunoglobulin production and growth in B-cells. IL-5 Protein activates kinases (LYN, SYK, and JAK2) through a receptor (IL5RA and CSF2RB subunits), propagating signals via RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer. IL-5 Protein, Cynomolgus (sf9, His) is the recombinant cynomolgus-derived IL-5 protein, expressed by Sf9 insect cells , with C-His labeled tag. The total length of IL-5 Protein, Cynomolgus (sf9, His) is 134 a.a., with molecular weight of ~14.6 kDa.
The IL5 protein is a cytokine that plays a key role in regulating the growth and differentiation of eosinophils, a type of white blood cell involved in allergic reactions and asthma. Dysregulation of IL5 protein is associated with a variety of allergic and inflammatory diseases. IL-5 Protein, Rabbit (HEK293, His) is the recombinant Rabbit-derived IL-5 protein, expressed by HEK293 , with N-6*His labeled tag. The total length of IL-5 Protein, Rabbit (HEK293, His) is 115 a.a., with molecular weight of 15-18 kDa.
The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag. The total length of IL-5 Protein, Human (Biotinylated, HEK293, His-Avi) is 115 a.a., with molecular weight of 18-24 kDa.
IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis. In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells. IL-5 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of IL-5 Protein, Mouse (HEK293, His) is 113 a.a., with molecular weight of 14-26 kDa.
IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis. In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells. IL-5 Protein, Mouse (HEK293, His-Avi) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-5 Protein, Mouse (HEK293, His-Avi) is 113 a.a., with molecular weight of ~16.03 kDa & 20-32 kDa, respectively.
The IL-5 Protein, predominantly expressed by T-lymphocytes and NK cells, is crucial for eosinophil survival, differentiation, and chemotaxis. It also affects B-cells, inducing immunoglobulin production, growth, and differentiation. IL-5 Protein activates kinases like LYN, SYK, and JAK2, which signal through RAS-MAPK and JAK-STAT5 pathways. It exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits. IL-5 Protein, Human (HEK293, His-Avi) is the recombinant human-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-5 Protein, Human (HEK293, His-Avi) is 115 a.a., with molecular weight of 18-25 kDa.
IL-5 protein is expressed by T lymphocytes and NK cells and regulates eosinophils, affecting their survival, differentiation and chemotaxis. In addition, IL-5 stimulates immunoglobulin production, growth, and differentiation of activated and resting B cells. IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) is the recombinant mouse-derived IL-5 protein, expressed by HEK293 , with N-His, N-Avi labeled tag. The total length of IL-5 Protein, Mouse (Biotinylated, HEK293, His-Avi) is 113 a.a., with molecular weight of 16 kDa & 20-35 kDa, respectively.
IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (Biotinylated, HEK293, His-Avi) is expressed by HEK293 cells and is a transmembrane protein (F343-C362) with His-Avi tags.
IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (HEK293, His-Avi) is expressed by HEK293 cells and is a transmembrane protein (F343-C362) with His-Avi tags.
IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation.IL-5R alpha Protein, Human (HEK293, His) is expressed by HEK293 cells with a C-6*His tag.
IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Mouse (HEK293, His) is expressed by HEK293 cells and is a transmembrane protein (L340-C361) with a C-6*His tag.
IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Mouse (sf9, His) is expressed by Sf9 insect cells and is a transmembrane protein (L340-C361) with a His tag.
IL-5R alpha protein is a cytokine receptor that is expressed on eosinophils, basophils and B cells and is involved in inflammation and immune regulation. IL-5R alpha Protein, Human (Q01344-2, HEK293, His) is expressed by HEK293 cells with a C-His tag.
The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Rat (HEK293, Fc) is the recombinant rat-derived CD131 protein, expressed by HEK293 , with C-hFc labeled tag. The total length of CD131 Protein, Rat (HEK293, Fc) is 440 a.a., with molecular weight of ~80-95 kDa.
The CD131 protein is a cell surface receptor that plays a critical role in the immune response and controls the generation and differentiation of hematopoietic progenitor cells. CD131 Protein, Human (HEK293, His) is the recombinant human-derived CD131 protein, expressed by HEK293 , with C-His labeled tag. The total length of CD131 Protein, Human (HEK293, His) is 427 a.a., with molecular weight of 50-55 kDa.
