2. Metabolic Enzyme/Protease
  3. GSNOR
  4. SPL-334

SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation.

For research use only. We do not sell to patients.

SPL-334

SPL-334 Chemical Structure

CAS No. : 688347-51-5

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Based on 1 publication(s) in Google Scholar

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Description

SPL-334 is a potent and selective S-Nitrosoglutathione reductase (GSNOR) inhibitor. SPL-334 causes a significant reduction in the production of Th2 cytokines IL-5 and IL-13 and the levels of the chemokine CCL11 (eotaxin-1) in the airways. SPL-334 can be used in research of allergic airway inflammation[1].

In Vivo

SPL-334 (0.1-1 mg/kg; Intranasal administration; daily, for 7 d; BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft) causes a reduction in allergic airway inflammation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c recipient mice with DO11.10 CD4+ Th2 xenograft[1]
Dosage: 0.1 or 1 mg/kg
Administration: Intranasal administration; daily, for 7 days
Result: Caused a significant reduction in the influx of lymphocytes and eosinophils into the airways and the level of EPO in the BALF.
Reduced the number of OVA-specific T cells and eosinophils during allergic airway inflammation.
Reduced in peribronchial inflammation and mucus secretion during airway inflammation.
Molecular Weight

433.50

Formula

C22H15N3O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=C(CSC2=NC3=C(C(N2CC4=CC=C(C(O)=O)C=C4)=O)SC=C3)C=CC=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (115.34 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3068 mL 11.5340 mL 23.0681 mL
5 mM 0.4614 mL 2.3068 mL 4.6136 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.6%

SDS (252 KB)

COA (254 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3068 mL 11.5340 mL 23.0681 mL 57.6701 mL
5 mM 0.4614 mL 2.3068 mL 4.6136 mL 11.5340 mL
10 mM 0.2307 mL 1.1534 mL 2.3068 mL 5.7670 mL
15 mM 0.1538 mL 0.7689 mL 1.5379 mL 3.8447 mL
20 mM 0.1153 mL 0.5767 mL 1.1534 mL 2.8835 mL
25 mM 0.0923 mL 0.4614 mL 0.9227 mL 2.3068 mL
30 mM 0.0769 mL 0.3845 mL 0.7689 mL 1.9223 mL
40 mM 0.0577 mL 0.2884 mL 0.5767 mL 1.4418 mL
50 mM 0.0461 mL 0.2307 mL 0.4614 mL 1.1534 mL
60 mM 0.0384 mL 0.1922 mL 0.3845 mL 0.9612 mL
80 mM 0.0288 mL 0.1442 mL 0.2884 mL 0.7209 mL
100 mM 0.0231 mL 0.1153 mL 0.2307 mL 0.5767 mL
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SPL-334 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SPL-334688347-51-5SPL334SPL 334GSNORS-nitrosoglutathione reductaseTh2 cytokinesIL-5IL-13chemokine CCL11allergic airway inflammationInhibitorinhibitorinhibit

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