IL-5 Protein, Canine (sf9, His)

IL-5 protein is expressed by T lymphocytes and NK cells and plays a crucial role in eosinophil survival, differentiation, and chemotaxis. It also promotes immunoglobulin production, growth and differentiation in B cells. IL-5 Protein, Canine (sf9, His) is the recombinant canine-derived IL-5 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of IL-5 Protein, Canine (sf9, His) is 134 a.a., with molecular weight of 17-19 kDa.

IL-5 Protein is a homodimeric cytokine mainly expressed by T-lymphocytes and NK cells, playing a crucial role in the survival, differentiation, and chemotaxis of eosinophils. It also acts on B-cells, promoting immunoglobulin production, growth, and differentiation. Mechanistically, IL-5 Protein exerts its effects by binding to a receptor composed of IL5RA and CSF2RB subunits, activating kinases such as LYN, SYK, and JAK2. This activation leads to signal propagation through the RAS-MAPK and JAK-STAT5 pathways. IL-5 Protein exists as a disulfide-linked homodimer and interacts with IL5RA and CSF2RB subunits.

Canine

Sf9 insect cells

N-His

Q95J76 (M1-S134)

403790  [NCBI]

17-19 kDa

Greater than 95% as determined by reducing SDS-PAGE

<1 EU/μg, determined by LAL method.