Mepolizumab (anti-IL5)
Based on 1 Customer Validation
Mepolizumab (anti-IL5) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma.
For research use only. We do not sell to patients.
- Purity: 97.50%
- CAS No.: 196078-29-2
- Molecular Weight:146.24 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Description
Isotype
Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity
Human
IC50 & Target
IL-5
In Vivo
Pharmacokinetic analysis of mepolizumab in cynomolgus monkeys[1]
| Route | Dose (mg/kg) | Cmax (μg/mL) | AUC0-INF_obs (μg·h/mL) | T1/2 (days) | Clobs (mL·h/kg) | Vss_obs (mL/kg) |
| i.v. | 300 | 6700 | 1405000 | 11.7 | 0.217 | 74.6 |
| i.v. | 3 | 89.1 | 14600 | 11.2 | 0.208 | 82.1 |