2. Immunology/Inflammation
  3. Interleukin Related
  4. Siltuximab

Siltuximab  (Synonyms: CNTO-328)

Cat. No.: HY-P9956 Purity: 99.90%
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Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research.

For research use only. We do not sell to patients.

Siltuximab Chemical Structure

Siltuximab Chemical Structure

CAS No. : 541502-14-1

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Based on 1 publication(s) in Google Scholar

Siltuximab Related Antibodies

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Description

Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research[1][2][3].

In Vivo

Siltuximab (intraperitoneal injection; 10 mg/kg; 3 times per week) inhibits the growth of lung cancer cells in xenograft mouse model[1].
Siltuximab (intraperitoneal injection; 20 mg/kg; twice per week; 6 w) inhibits the growth of MCF-7 tumor in xenograft model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 nu/nu mice injected with H1650 (adenocarcinoma), H322 (adenocarcinoma), or H157 (squamous) cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week
Result: Repressed PY-STAT3 levels stimulated by IL-6 in H322 cells.
Repressed PY-STAT3 levels in H1650 cells.
Inhibited the growth of tumors with H322 and CAF cells.
Inhibited the growth of tumors with H1650 and CAF cells.
Animal Model: Female NOD-SCID mice with MCF-7 tumor[4]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg; twice per week; 6 weeks
Result: Blocked MCF-7 engraftment, induced regressions in 90% of tumors.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Siltuximab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.90%

COA (291 KB)

Handling Instructions (2659 KB)
References
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Siltuximab Related Classifications

  • Molarity Calculator

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Siltuximab541502-14-1CNTO-328CNTO328CNTO 328Interleukin RelatedILantitumor activityMulticentric Castleman's DiseaseMCDCOVID-19Inhibitorinhibitorinhibit

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