1. Immunology/Inflammation
  2. Interleukin Related
  3. Siltuximab

Siltuximab  (Synonyms: CNTO-328)

Cat. No.: HY-P9956 Purity: ≥99.0%
COA

Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research.

For research use only. We do not sell to patients.

Siltuximab Chemical Structure

Siltuximab Chemical Structure

CAS No. : 541502-14-1

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Based on 1 publication(s) in Google Scholar

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Description

Siltuximab is an anti-IL-6 (interleukin-6) monoclonal antibody, and shows antitumor activity. Siltuximab can be used in Multicentric Castleman's Disease (MCD) and COVID-19 research[1][2][3].

Isotype

Human IgG1 kappa

Recommend Isotype Controls
Species

Chimeric

In Vivo

Siltuximab (intraperitoneal injection; 10 mg/kg; 3 times per week) inhibits the growth of lung cancer cells in xenograft mouse model[1].
Siltuximab (intraperitoneal injection; 20 mg/kg; twice per week; 6 w) inhibits the growth of MCF-7 tumor in xenograft model[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female CD-1 nu/nu mice injected with H1650 (adenocarcinoma), H322 (adenocarcinoma), or H157 (squamous) cells[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection; 10 mg/kg; 3 times per week
Result: Repressed PY-STAT3 levels stimulated by IL-6 in H322 cells.
Repressed PY-STAT3 levels in H1650 cells.
Inhibited the growth of tumors with H322 and CAF cells.
Inhibited the growth of tumors with H1650 and CAF cells.
Animal Model: Female NOD-SCID mice with MCF-7 tumor[4]
Dosage: 20 mg/kg
Administration: Intraperitoneal injection; 20 mg/kg; twice per week; 6 weeks
Result: Blocked MCF-7 engraftment, induced regressions in 90% of tumors.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Siltuximab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Purity: ≥99.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Siltuximab
Cat. No.:
HY-P9956
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