1. Immunology/Inflammation
  2. Interleukin Related
  3. Brodalumab

Brodalumab  (Synonyms: AMG 827; KHK4827)

Cat. No.: HY-P9925

Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis.

For research use only. We do not sell to patients.

CAS No. : 1174395-19-7

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1 mg USD 190 In-stock
5 mg USD 480 In-stock
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Based on 2 publication(s) in Google Scholar

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Description

Brodalumab (AMG 827) is a human anti-interleukin-17-receptor IgG2 monoclonal antibody that can be used for the research of moderate-to-severe plaque psoriasis and rheumatoid arthritis[1][2].

Isotype

Human IgG2 kappa

Recommend Isotype Controls
Species

Human

IC50 & Target

IL-17R[1]

In Vitro

Brodalumab (AMG 827) blocks the biological activity of IL-17A, IL-17F and IL17-A/F heterodimer signaling through the IL-17RA/RC complex, as well as IL-25 (IL-17E) signaling through the IL-17RA/RB complex[2].
Brodalumab is capable of inhibiting the inflammatory process in psoriasis[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Brodalumab]

Shipping

Shipping with dry ice.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized IL-17RA Protein, Human can bind Brodalumab. The EC50 for this effect is 7.1 ng/mL.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Brodalumab
Cat. No.:
HY-P9925
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