Mepolizumab
Based on 1 Customer Validation
Mepolizumab (SB 240563) is a humanized monoclonal antibody that binds to and neutralizes interleukin-5 (IL-5), the major cytokine involved in eosinophil proliferation, activation, and survival. Mepolizumab can be used for the research of eosinophilic granulomatosis with polyangiitis (EGPA) and severe eosinophilic asthma.
For research use only. We do not sell to patients.
- Purity: 99.4%
- CAS No.: 196078-29-2
- Molecular Weight:146.24 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Human IgG1 kappa
Human
IL-5
Mepolizumab shows nearly linear PK after intravenous administration over a 6000-fold dose range (0.05-300 mg/kg), inhibiting eosinophil proliferation with an IC50 of 1.43 mg/mL[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Pharmacokinetic analysis of mepolizumab in cynomolgus monkeys[1]
| Route | Dose (mg/kg) | Cmax (μg/mL) | AUC0-INF_obs (μg·h/mL) | T1/2 (days) | Clobs (mL·h/kg) | Vss_obs (mL/kg) |
| i.v. | 300 | 6700 | 1405000 | 11.7 | 0.217 | 74.6 |
| i.v. | 3 | 89.1 | 14600 | 11.2 | 0.208 | 82.1 |