1. Immunology/Inflammation
  2. Interleukin Related
  3. Secukinumab

Secukinumab (Synonyms: AIN457)

Cat. No.: HY-P9927
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Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis.

For research use only. We do not sell to patients.

Secukinumab Chemical Structure

Secukinumab Chemical Structure

CAS No. : 1229022-83-6

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Description

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis[1][2].

IC50 & Target[1]

IL-17A

 

In Vitro

Secukinumab is a fully human monoclonal antibody that selectively binds to and neutralizes interleukin-17A[2].
Secukinumab (1 nM, 10 nM, and 100 nM) inhibits IL17A and IL17A/TNF a-induced increase in protein levels of IL6 in human astrocytes[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

CAS No.
SMILES

[Secukinumab]

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Keywords:

SecukinumabAIN457AIN 457AIN-457Interleukin RelatedILpsoriasisfirst-in-classselectiveneutralizesinterleukinarthritisInhibitorinhibitorinhibit

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Secukinumab
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