1. Immunology/Inflammation
  2. Interleukin Related
  3. Secukinumab

Secukinumab  (Synonyms: AIN457)

Cat. No.: HY-P9927 Purity: 98.10%
COA

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis.

For research use only. We do not sell to patients.

CAS No. : 1229022-83-6

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5 mg USD 620 In-stock
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE Secukinumab

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Description

Secukinumab (AIN457) is a high affinity, human monoclonal antibody targeted against interleukin (IL)-17A. Secukinumab is the first-in-class anti-IL-17 agent used for the research of plaque psoriasis, ankylosing spondylitis and psoriatic arthritis[1][2].

Isotype

Human IgG1 kappa

Recommend Isotype Controls
Species

Human

IC50 & Target[1]

IL-17A

 

In Vitro

Secukinumab is a fully human monoclonal antibody that selectively binds to and neutralizes interleukin-17A[2].
Secukinumab (1 nM, 10 nM, and 100 nM) inhibits IL17A and IL17A/TNF a-induced increase in protein levels of IL6 in human astrocytes[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Secukinumab]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
Purity & Documentation

Purity: ≥99.20%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Secukinumab
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HY-P9927
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