IL17A - interleukin 17A Gene
Also Known as IL17; CTLA8; IL-17; ILA17; CTLA-8; IL-17A
Species: Homo sapiens
About IL17A
This gene has 1 transcript (splice variant), 97 orthologues and 5 paralogues. Low expression observed in reference dataset.
Summary
This gene is a member of the IL-17 Receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and Cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A. [provided by RefSeq, Sep 2020]
IL17A Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_002190.3 | NP_002181.1 | interleukin-17A precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables cytokine activity |
IDA
IDA: Inferred from direct assay
|
12297109 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
23695682 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| is active in extracellular space |
IDA
IDA: Inferred from direct assay
|
12297109 | GOA |
IL17A Protein Structure
IL17: Interleukin-17 (68 - 148)
- 0
- 100
- 155 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
interleukin-17A |
|
|
IL17A Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
IL17A | Q16552 | DPH2 | Homo sapiens | Q9BQC3 | 25416956 | |
|
Intra
|
IL17A | Q16552 | KCNIP4 | Homo sapiens | Q6PIL6 | 32296183 |
Recombinant IL17A Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P7036 | IL-17A Protein, Human | Q16552 (G24-A155) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P7373 | IL-17A Protein, Human (CHO, His) | Q16552 (G24-A155) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P70527 | IL-17A Protein, Human (HEK293, His) | Q16552 (G24-A155) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P72589 | IL-17A/F Heterodimer Protein, Human (HEK293, His) | Q16552 (G24-A155)&AAH70124.1 (R31-Q163) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P73171 | IL-17A Protein, Human (CHO) | Q16552 (G24-A155) | ≥ 90%, as determined by reducing SDS-PAGE. |
| HY-P73172 | IL-17A Protein, Human (T26A, sf9, His) | Q16552 (G24-A155, T26A) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P77713 | IL-17A/F Heterodimer Protein, Human (Biotinylated, HEK293, His-Avi) | Q16552 (G24-A155)&Q96PD4 (R31-Q163) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P78157 | IL-17A Protein, Human (Biotinylated, HEK293, His-Avi) | Q16552 (G24-A155) | ≥ 95%, as determined by Bis-Tris PAGE. |
| HY-P700104AF | Animal-Free IL-17A Protein, Human (His) | Q16552 (I20-A155) | ≥ 95%, as determined by reducing SDS-PAGE. |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Trichinosis |
|
|
| Systemic Scleroderma |
|
|
| Autoimmune Lymphoproliferative Syndrome |
|
|
| Perinatal Necrotizing Enterocolitis |
|
|
| Primary Progressive Multiple Sclerosis |
|
|
| Mycoplasma Pneumoniae Pneumonia |
|
|
| Nail Disease |
|
|
| Tularemia |
|
|
| Alopecia |
|
|
| Myelitis |
|
|
| Leprosy 3 |
|
|
| Histiocytosis |
|
|
| Chromium Allergic Contact Dermatitis |
|
|
| Iridocyclitis |
|
|
| Radiculopathy |
|
|
| Microscopic Colitis |
|
|
| Schistosomiasis |
|
|
| Orchitis |
|
|
| West Nile Virus |
|
|
| Lichen Planus |
|
|
| Spondylitis |
|
|
| Acute Generalized Exanthematous Pustulosis |
|
|
| Severe Acute Respiratory Syndrome |
|
|
| Good Syndrome |
|
|
| Appendicitis |
|
|
| Nervous System Disease |
|
|
| Alopecia Areata |
|
|
| Septic Arthritis |
|
|
| Allergic Disease |
|
|
| Interstitial Lung Disease 2 |
|
|
| Vaginitis |
|
|
| Autoimmune Disease Of Skin And Connective Tissue |
|
|
| Subcutaneous Mycosis |
|
|
| Ileitis |
|
|
| Systemic Lupus Erythematosus |
|
|
| Chorioretinitis |
|
|
| Norwegian Scabies |
|
|
| Psoriasis 11 |
|
|
| Autoimmune Vasculitis |
|
|
| Crohn'S Disease |
|
|
| Autoimmune Disease Of Eyes, Ear, Nose And Throat |
|
|
| Hypothyroidism |
|
|
| Collagenous Colitis |
|
|
| Allergic Conjunctivitis |
|
|
| Localized Scleroderma |
|
|
| Salmonellosis |
|
|
| Tendinitis |
|
|
| Osteonecrosis |
|
|
| Mastitis |
|
|
| Phaeohyphomycosis |
|
|
| Childhood-Onset Asthma |
|
|
| Progressive Relapsing Multiple Sclerosis |
|
|
| Progressive Multifocal Leukoencephalopathy |
|
|
| Rheumatic Heart Disease |
|
|
| Allergic Contact Dermatitis |
|
|
| Rosacea |
|
|
| Prostatitis |
|
|
| Vaginal Disease |
|
|
| Posterior Uveitis |
|
|
| Cellulitis |
|
|
| Angelucci'S Syndrome |
|
|
| Meningitis |
|
|
| Lymphangioma |
|
|
| Nephrotic Syndrome |
|
|
| Transient Arthritis |
|
|
| Respiratory Allergy |
|
|
| Bronchial Disease |
|
|
| Guillain-Barre Syndrome |
|
|
| Palladium Allergic Contact Dermatitis |
|
|
| Psoriasis 1 |
|
|
| Visceral Leishmaniasis |
|
|
| Intestinal Schistosomiasis |
|
|
| Cystic Fibrosis |
|
|
| Pneumonic Plague |
|
|
| Cutaneous Candidiasis |
|
|
| Pyoderma |
|
|
| Pneumocystosis |
|
|
| Nasal Cavity Disease |
|
|
| Hyper Ige Syndrome |
|
|
| Cryptococcal Meningitis |
|
|
| Hypopyon |
|
|
| Stomatitis |
|
|
| Trachoma |
|
|
| Bronchiolitis Obliterans |
|
|
| Type 2 Diabetes Mellitus |
|
|
| Mycetoma |
|
|
| Opportunistic Mycosis |
|
|
| Autoimmune Myocarditis |
|
|
| Myocardial Infarction |
|
|
| Granulomatosis With Polyangiitis |
|
|
| Parasitic Helminthiasis Infectious Disease |
|
|
| Amebiasis |
|
|
| Silicosis |
|
|
| Reactive Arthritis |
|
|
| Giardiasis |
|
|
| Peripheral Nervous System Disease |
|
|
| Ichthyosis |
|
|
| Osteoarthritis |
|
|
| Sclerosing Cholangitis |
|
|
| Proteasome-Associated Autoinflammatory Syndrome 1 |
|
|
| Toxoplasmosis |
|
|
| Intrinsic Asthma |
|
|
| Ankylosing Spondylitis 1 |
|
|
| Autoimmune Disease Of Cardiovascular System |
|
|
| Coronavirus Infectious Disease |
|
|
| Inflammatory Bowel Disease |
|
|
| Tenosynovitis |
|
|
| Leukocyte Adhesion Deficiency, Type I |
|
|
| Ocular Toxoplasmosis |
|
|
| Acne |
|
|
| Sapho Syndrome |
|
|
| Chemical Colitis |
|
|
| Uveal Disease |
|
|
| Cholangitis, Primary Sclerosing |
|
|
| Dermatitis |
|
|
| Juvenile Rheumatoid Arthritis |
|
|
| Relapsing-Remitting Multiple Sclerosis |
|
|
| Leukocyte Disease |
|
|
| Pneumonia |
|
|
| Asthma |
|
|
| Myelofibrosis |
|
|
| Contact Dermatitis |
|
|
| Infectious Anterior Uveitis |
|
|
| Primary Systemic Mycosis |
|
|
| Sporotrichosis |
|
|
| Vitiligo-Associated Multiple Autoimmune Disease Susceptibility 1 |
|
|
| Mycobacterium Tuberculosis 1 |
|
|
| Lyme Disease |
|
|
| Yellow Fever |
|
|
| Brucellosis |
|
|
| Esophageal Candidiasis |
|
|
| Chronic Mucocutaneous Candidiasis |
|
|
| Dermatitis Herpetiformis |
|
|
| Pemphigus |
|
|
| Autoimmune Polyendocrine Syndrome Type 1 |
|
|
| Eyelid Disease |
|
|
| Hair Disease |
|
|
| Lichen Disease |
|
|
| Parasitic Protozoa Infectious Disease |
|
|
| Temporal Arteritis |
|
|
| Short Syndrome |
|
|
| Arthritis |
|
|
| Psoriasis 8 |
|
|
| Chronic Asthma |
|
|
| Immune Deficiency Disease |
|
|
| Potocki-Shaffer Syndrome |
|
|
| Secondary Progressive Multiple Sclerosis |
|
|
| Invasive Aspergillosis |
|
|
| Behcet Syndrome |
|
|
| Commensal Bacterial Infectious Disease |
|
|
| Inflammatory Diarrhea |
|
|
| Coccidioidomycosis |
|
|
| Candidiasis |
|
|
| Panuveitis |
|
|
| Colonic Benign Neoplasm |
|
|
| Celiac Disease 1 |
|
|
| Extrinsic Cardiomyopathy |
|
|
| Human Cytomegalovirus Infection |
|
|
| Spondyloarthropathy |
|
|
| Myositis |
|
|
| Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked |
|
|
| Blepharitis |
|
|
| Severe Covid-19 |
|
|
| Psoriasis |
|
|
| Aggressive Periodontitis |
|
|
| Oral Candidiasis |
|
|
| Cardiovascular System Disease |
|
|
| Blastomycosis |
|
|
| Allergic Bronchopulmonary Aspergillosis |
|
|
| Influenza |
|
|
| Exanthem |
|
|
| Body Mass Index Quantitative Trait Locus 11 |
|
|
| Combined Immunodeficiency |
|
|
| Leishmaniasis |
|
|
| Peritonitis |
|
|
| Bacterial Infectious Disease |
|
|
| Demyelinating Disease |
|
|
| Lung Disease |
|
|
| Rectal Disease |
|
|
| Inflammatory Bowel Disease 1 |
|
|
| Gastritis |
|
|
| Aortitis |
|
|
| Chagas Disease |
|
|
| Lacrimal Apparatus Disease |
|
|
| Enthesopathy |
|
|
| Coccidiosis |
|
|
| Echinococcosis |
|
|
| Pulmonary Disease, Chronic Obstructive |
|
|
| Intermediate Uveitis |
|
|
| Multiple Sclerosis |
|
|
| Neutrophilic Dermatosis, Acute Febrile |
|
|
| Cryptococcosis |
|
|
| Psoriatic Arthritis |
|
|
| Autoimmune Disease Of Gastrointestinal Tract |
|
|
| Keratitis, Hereditary |
|
|
| Skin Disease |
|
|
| Suppurative Uveitis |
|
|
| Autoimmune Uveitis |
|
|
| Meningovascular Neurosyphilis |
|
|
| Ileus |
|
|
| Pustulosis Of Palm And Sole |
|
|
| Fungal Meningitis |
|
|
| Autism |
|
|
| Uveitis |
|
|
| Endocarditis |
|
|
| Pre-Eclampsia |
|
|
| Autoimmune Disease Of Blood |
|
|
| Vulvovaginal Candidiasis |
|
|
| T2-Low Asthma |
|
|
| Chronic Conjunctivitis |
|
|
| Sweat Gland Disease |
|
|
| B Cell Deficiency |
|
|
| Hypersensitivity Reaction Type Iv Disease |
|
|
| Neuromyelitis Optica |
|
|
| Autoimmune Disease Of Urogenital Tract |
|
|
| Iritis |
|
|
| Chickenpox |
|
|
| Bronchiolitis |
|
|
| Common Cold |
|
|
| Hidradenitis |
|
|
| Primary Biliary Cholangitis |
|
|
| Extrapulmonary Tuberculosis |
|
|
| Heart Disease |
|
|
| Psoriasis 14, Pustular |
|
|
| Osteoporosis |
|
|
| Folliculitis |
|
|
| Dermatitis, Atopic |
|
|
| Metal Allergy |
|
|
| Chronic Granulomatous Disease |
|
|
| Dermatomyositis |
|
|
| Syphilis |
|
|
| Crescentic Glomerulonephritis |
|
|
| Polyradiculoneuropathy |
|
|
| Acute Proliferative Glomerulonephritis |
|
|
| Cholangitis |
|
|
| Arthropathy |
|
|
| Lymphoid Interstitial Pneumonia |
|
|
| Chronic Fatigue Syndrome |
|
|
| Hypertension, Essential |
|
|
| Autoimmune Disease Of Exocrine System |
|
|
| Seborrheic Dermatitis |
|
|
| Skin Sarcoidosis |
|
|
| Rhinitis |
|
|
| Crohn'S Colitis |
|
|
| Aphthous Stomatitis |
|
|
| Optic Nerve Disease |
|
|
| Fungal Infectious Disease |
|
|
| Chikungunya |
|
|
| External Ear Disease |
|
|
| Dacryoadenitis |
|
|
| Central Nervous System Disease |
|
|
| Sympathetic Ophthalmia |
|
|
| Otitis Media |
|
|
| Autoimmune Polyendocrine Syndrome |
|
|
| Bacterial Pneumonia |
|
|
| Primary Bacterial Infectious Disease |
|
|
| Corneal Disease |
|
|
| Inflammatory Bowel Disease 18 |
|
|
| Allergic Rhinitis |
|
|
| Autoimmune Cholangitis |
|
|
| Familial Mediterranean Fever |
|
|
| Autoimmune Disease Of Peripheral Nervous System |
|
|
| Nose Disease |
|
|
| Immune System Disease |
|
|
| Otitis Externa |
|
|
| Viral Infectious Disease |
|
|
| Paranasal Sinus Disease |
|
|
| Gingival Disease |
|
|
| Eye Disease |
|
|
| Food Allergy |
|
|
| Tinea Pedis |
|
|
| Hyper Ige Recurrent Infection Syndrome 1 |
|
|
| Integumentary System Disease |
|
|
| Granuloma Annulare |
|
|
| Scleral Disease |
|
|
| Conjunctival Disease |
|
|
| Autoimmune Disease Of Musculoskeletal System |
|
|
| Neurosyphilis |
|
|
| Langerhans Cell Histiocytosis |
|
|
| Churg-Strauss Syndrome |
|
|
| Autoimmune Disease Of Central Nervous System |
|
|
| Dry Eye Syndrome |
|
|
| Osteonecrosis Of The Jaw |
|
|
| Choroiditis |
|
|
| Vasculitis |
|
|
| Autoimmune Disease |
|
|
| Colitis |
|
|
| Periodontitis |
|
|
| Ankylosis |
|
|
| Disease By Infectious Agent |
|
|
| Polymyositis |
|
|
| Diabetes Mellitus |
|
|
| Central Nervous System Vasculitis |
|
|
| Bone Inflammation Disease |
|
|
| Respiratory Failure |
|
|
| Dilated Cardiomyopathy |
|
|
| Pneumonic Tularemia |
|
|
| Angular Cheilitis |
|
|
| Vogt-Koyanagi-Harada Disease |
|
|
| T2-High Asthma |
|
|
| Hidradenitis Suppurativa |
|
|
| Autoimmune Glomerulonephritis |
|
|
| Autoimmune Disease Of Endocrine System |
|
|
| Xerophthalmia |
|
|
| T Cell Deficiency |
|
|
| Colorectal Cancer |
|
|
| Restless Legs Syndrome |
|
|
| Lymph Node Disease |
|
|
| Bronchopneumonia |
|
|
| Spondyloarthropathy 1 |
|
|
| Sebaceous Gland Disease |
|
|
| Scrub Typhus |
|
|
| Birdshot Chorioretinopathy |
|
|
| Connective Tissue Disease |
|
|
| Thymoma |
|
|
| Chlamydia |
|
|
| Cystitis |
|
|
| Nasopharyngitis |
|
|
| Cutaneous Leishmaniasis |
|
|
| Malaria |
|
|
| Sarcoidosis 1 |
|
|
| Allergic Asthma |
|
|
| Pemphigoid |
|
|
| Acute Asthma |
|
|
| Urticaria |
|
|
| Middle Ear Disease |
|
|
| Lipoprotein Quantitative Trait Locus |
|
|
| Rheumatoid Arthritis |
|
|
| Dermatophytosis |
|
|
| Myocarditis |
|
|
| Purpura |
|
|
| Splenic Disease |
|
|
| Pityriasis Rubra Pilaris |
|
|
| Trypanosomiasis |
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | IL17A | VGNC | VGNC:41942 |
| Mus musculus | IL17A | MGD | MGI:107364 |
| Bos taurus | IL17A | VGNC | VGNC:30117 |
| Rattus norvegicus | IL17A | RGD | RGD:2888 |
| Macaca mulatta | IL17A | VGNC | VGNC:81081 |
| Others | IL17A | NCBI |