Tibulizumab
Based on 1 Customer Validation
Tibulizumab (LY 3090106) is a tetravalent bispecific monoclonal antibody targeting B-cell activating factor (BAFF) and IL-17A with Kd values of 60 pM and 14 pM, respectively. Tibulizumab can be used for autoimmune disease research.
For research use only. We do not sell to patients.
- Purity: 98.86%
- CAS No.: 1849636-24-3
- Molecular Weight:201.43 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
IgG4-kappa-[scFv-heavy-kappa]2
Human
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IL-17A 14 pM (Kd) |
BAFF 60 pM (Kd) |
Tibulizumab (LY 3090106) binds to mouse BAFF with a KD of 340 nM and does not bind to mouse IL-17. Tibulizumab binds to cynomolgus BAFF and cynomolgus IL-17 with KD of 26.8 pM and 19 pM, respectively[1].
In HT-29 cells, Tibulizumab antagonizes the IL-17-induced secretion of CXCL1 in a concentration-dependent manner (IC50 of 2.00 nM). In T1165 cells, Tibulizumab blocks BAFF-induced proliferation in a concentration-dependent manner (IC50 of 0.064 nM). Tibulizumab simultaneously binds and blocks both BAFF and IL-17[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
In cynomolgus monkey, Tibulizumab (i.v, 0.3, 1, 5, or 20 mg/kg; or s.c, 5 mg/kg) suppresses B cell development and survival and remains functionally intact in circulation, with a prolonged half-life[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG4-kappa-[scFv-heavy-kappa]2
ELISA, FACS, Functional assay
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Immobilized BAFF/TNFSF13B Protein, Human (CHO, HY-P7003) can bind Tibulizumab. The EC50 for this effect is 36.68 ng/mL. -
Immobilized IL-17A Protein, Human (HEK293, His, HY-P70527) can bind Tibulizumab. The EC50 for this effect is 19.5 ng/mL.
Chemical Information
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CAS No. 1849636-24-3
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Appearance Liquid
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Molecular Weight 201.43 kDa
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Color Colorless to light yellow
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SMILES
[Tibulizumab]
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Synonyms
LY 3090106
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (257 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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