2. Apoptosis Immunology/Inflammation
  3. TNF Receptor IFNAR Interleukin Related
  4. Aritinercept

Aritinercept  (Synonyms: AUR-200)

Cat. No.: HY-P992101 Purity: 99.90%
COA
Technical Support

Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, IL-17A, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus.

For research use only. We do not sell to patients.

Aritinercept

Aritinercept Chemical Structure

CAS No. : 3057276-00-0

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Aritinercept Related Antibodies

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Description

Aritinercept (AUR-200) is a recombinant fusion protein targeting TNFSF13B/BAFF/CD257. Aritinercept neutralizes BAFF and APRIL (TNFSF13), reduces B cell proliferation, suppresses peripheral B cells, lowers serum immunoglobulins. Aritinercept reduces renal damage markers, decreases IFNγ, IL-17A, and anti-dsDNA autoantibodies, and improves survival in a mouse model of SLE. ritinercept can be used for the research of systemic lupus erythematosus[1].

Species Reactivity

Human
IC50 & Target[1]

IL-17A

 

In Vitro

Aritinercept exhibits high binding affinity (Kd) to human BAFF (117 pM), human APRIL (25 pM), mouse BAFF (31 pM), and mouse APRIL (505 pM) in a cell-free surface plasmon resonance binding assay[1].
Aritinercept potently inhibits human APRIL (IC50 = 0.002 nM), mouse BAFF (IC50 = 1.5 nM), and mouse APRIL (IC50 = 2.7 nM) in a cell-free competitive ELISA, with no detectable inhibition of human BAFF[1].
Aritinercept reduces BAFF and APRIL-costimulated proliferation of human primary B cells and mouse splenocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Aritinercept Related Antibodies
In Vivo

Aritinercept (1-10 mg/kg; s.c.; weekly; 6 weeks) significantly improves survival, reduces proteinuria and renal histologic damage, lowers proinflammatory cytokines, and dose-dependently decreases anti-dsDNA autoantibodies in a mouse model of SLE[1].
Aritinercept (1 mg/kg; s.c.; single dose) suppresses peripheral B cells, and (5-80 mg/kg; s.c.; weekly; 4 weeks) induces sustained reductions in all serum immunoglobulins in healthy cynomolgus monkeys[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NZBxNZW F1 (randomized by body weight and proteinuria scores)[1]
Dosage: 1 mg/kg; 3 mg/kg; 10 mg/kg
Administration: s.c.; weekly; 6 weeks
Result: Significantly improved survival at all doses tested.
Reduced proteinuria.
Decreased histological markers of renal damage.
Significantly decreased serum IFNγ and IL-17A levels at all doses.
Dose-dependently reduced serum anti-dsDNA autoantibodies.
Animal Model: Cynomolgus monkeys[1]
Dosage: 1 mg/kg; 5 mg/kg; 20 mg/kg; 80 mg/kg
Administration: s.c.; single dose (1 mg/kg); weekly; 4 weeks (5, 20, 80 mg/kg)
Result: Suppressed peripheral B cells (single 1 mg/kg subcutaneous dose).
Induced sustained reductions in all serum immunoglobulins (weekly subcutaneous doses of 5, 20, or 80 mg/kg for 4 weeks).
Gene ID

10673  [NCBI]

Accession
Target

TNFSF13B/BAFF/CD257
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
CAS No.
SMILES

[Aritinercept]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 99.90%

COA (231 KB)

Inhibitory Antibodies User Guide (603 KB)
References
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Aritinercept Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Aritinercept3057276-00-0AUR-200AUR200AUR 200TNF ReceptorIFNARInterleukin RelatedTumor Necrosis Factor ReceptorTNFRInterferon-α/β receptorInterferon-alpha/beta receptor ILIFNγIL-17Asystemic lupus erythematosusrenal damage markersanti-dsDNA autoantibodiesB cell proliferationserum immunoglobulinsperipheral B cellsBAFFAPRILInhibitorinhibitorinhibit

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