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Cat. No.: HY-181827

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IL-17-IN-7

IL-17-IN-7 (Compound 23) is a IL-17 inhibitor with a pIC₅₀ of 7.1 against IL-17A.

For research use only. We do not sell to patients.

Formula: C₂₂H₂₇BrF₂N₈O
Molecular Weight:537.40

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IL-17-IN-7 Chemical Structure

Size

Price

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Quantity

Sample (0.1mg)

In-stock

(In Japan)

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IL-17-IN-7 (Compound 23) is a IL-17 inhibitor with a pIC₅₀ of 7.1 against IL-17A^[1].

IC₅₀ & Target^[1]

IL-17A

7.1 (pIC₅₀)

All Interleukin Related Isoforms :

In Vitro

IL-17-IN-7 potently binds to recombinant human IL-17A, with a biochemical pIC₅₀ of 7.1 ± 0.0 in the TR-FRET competitive binding assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 537.40
Formula C₂₂H₂₇BrF₂N₈O
SMILES

CN1N=CC=C1C(N[C@@H](C2CCC(F)(CC2)F)C3=NC(C[C@H]4CCC5=NC=C(N5C4)Br)=NN3)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Bauer MR, et al. Harnessing Glutamine-117 Plasticity toward Structure-Based Identification of Triazole IL-17 Inhibitors. J Med Chem. 2025;68(24):26494-26512. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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