IL-17A modulator-2
Based on 2 publication(s) in Google Scholar
IL-17A modulator-2 is a IL-17A modulator, extracted from patent WO2021239743+A1, example 27. IL-17A modulator-2 inhibits the biological action of IL-17A with a pIC50 of 8.3. IL-17A modulator-2 can be used for the research of diseases or disorders associated with modulation of IL-17A activity including diseases with an immune component or autoimmune pathol, cancer and neurodegenerative disorders.
For research use only. We do not sell to patients.
- Purity: 98.44%
- CAS No.: 2748749-47-3
- Formula: C33H31N5O5
- Molecular Weight:577.63
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Storage:
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) IL-17A modulator-2
More
Biological Activity
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IL-17A 8.3 (pIC50) |
Chemical Information
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CAS No. 2748749-47-3
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Appearance Solid
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Molecular Weight 577.63
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Formula C33H31N5O5
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Color White to off-white
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SMILES
O=C(C1=CC=NN1C)N[C@H](C(NC2=CC=C(C3=C(OC)C=[N+]([O-])C=C3OC)C=C2)=O)C(C4=CC=CC=C4)C5=CC=CC=C5
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture and light
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Int Immunopharmacol
Phellodendrine ameliorates intestinal inflammation and protects mucosal barrier via modulating COL1A1, VCAM1 and IL-17 a. [Abstract]2025 Apr 16:152:114403. PMID: 40101527 -
Sci Rep
Expression of interleukin-17 in oral tongue squamous cell carcinoma and its effect on biological behavior. [Abstract]2025 Jan 25;15(1):3195. PMID: 39863794
Solvent & Solubility
DMSO : 100 mg/mL (173.12 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.7312 mL | 8.6561 mL | 17.3121 mL | 43.2803 mL |
| 5 mM | 0.3462 mL | 1.7312 mL | 3.4624 mL | 8.6561 mL | |
| 10 mM | 0.1731 mL | 0.8656 mL | 1.7312 mL | 4.3280 mL | |
| 15 mM | 0.1154 mL | 0.5771 mL | 1.1541 mL | 2.8854 mL | |
| 20 mM | 0.0866 mL | 0.4328 mL | 0.8656 mL | 2.1640 mL | |
| 25 mM | 0.0692 mL | 0.3462 mL | 0.6925 mL | 1.7312 mL | |
| 30 mM | 0.0577 mL | 0.2885 mL | 0.5771 mL | 1.4427 mL | |
| 40 mM | 0.0433 mL | 0.2164 mL | 0.4328 mL | 1.0820 mL | |
| 50 mM | 0.0346 mL | 0.1731 mL | 0.3462 mL | 0.8656 mL | |
| 60 mM | 0.0289 mL | 0.1443 mL | 0.2885 mL | 0.7213 mL | |
| 80 mM | 0.0216 mL | 0.1082 mL | 0.2164 mL | 0.5410 mL | |
| 100 mM | 0.0173 mL | 0.0866 mL | 0.1731 mL | 0.4328 mL |
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