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Art. -Nr.: HY-W145695

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Chitoheptaose

Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis.

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CAS. Nr.: 68232-35-9
Formel: C₄₂H₇₉N₇O₂₉
Molecular Weight:1146.11

Speicherung:

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Chitoheptaose Chemical Structure

CAS. Nr.: 68232-35-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

IL-1β

IL-17A

IL-10

Alle Interleukin Related Isoform-spezifische Produkte anzeigen :

In Vitro

Chitoheptaose (100 μM; 24 h prior to 6 h LPS stimulation at 200 ng/mL) exerts anti-inflammatory activity in LPS-stimulated RAW264.7 cells, with activity greater than chitopentaose and chitohexaose, ranking third among tested chitosan oligosaccharides with degree of polymerization >4^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ELISA Assay^[1]

Cell Line:

RAW264.7 macrophage cells
Concentration:

100 μM
Incubation Time:

24 h (prior to 6 h LPS stimulation at 200 ng/mL)
Result:

Reduced levels of proinflammatory cytokines IL-1β, IL-17A, and IFN-γ.
Increased levels of anti-inflammatory cytokine IL-10.
Showed significantly greater anti-inflammatory activity than chitopentaose and chitohexaose, but less than chitooctaose (p < 0.05).

In Vivo

Chitoheptaose (100 μM; p.o.; daily; 30 days) exerts superior cardioprotective effects in a rat autoimmune myocarditis model via enhanced antioxidant, anti-inflammatory, and antiapoptotic activities, improving cardiac function, reducing myocardial injury, and modulating inflammatory and apoptotic markers more effectively than other tested chitosan oligosaccharides (p < 0.05)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

SPF rats (8-week-old, 200-220 g, experimental autoimmune myocarditis model induced by subcutaneous injection of porcine cardiac myosin emulsified with complete Freund’s adjuvant on day 1 and day 8)^[1]
Dosage:

100 μM
Administration:

p.o.; daily; 30 days
Result:

Reduced left ventricular internal diameter in end diastole (LVIDd) and left ventricular internal diameter in end systole (LVIDs) significantly compared with other chitosan oligosaccharides (p < 0.05).
Increased ejection fraction (EF) and fractional shortening (FS) significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced myocardial histopathological scores and inflammatory cell infiltration more effectively than other chitosan oligosaccharides (p < 0.05).
Lowered serum levels of proinflammatory cytokines IL-1β, IL-17A, and IFN-γ, and increased anti-inflammatory cytokine IL-10 significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced cardiac tissue levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced relative mRNA and protein levels of proapoptotic factors caspase 3 and BAX, and increased relative mRNA and protein levels of antiapoptotic factor BCL-2 significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced IHC scores for caspase 3 and BAX, and increased IHC scores for BCL-2 significantly compared with other chitosan oligosaccharides (p < 0.05).
Achieved a serum level of 45 μM after treatment.

Chemical Information

CAS. Nr. 68232-35-9
Appearance Solid
Molecular Weight 1146.11
Formel C₄₂H₇₉N₇O₂₉
Color White to off-white
SMILES

OC[C@@H](O[C@H]([C@@H]([C@H]1O)N)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)N)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](N)C=O)CO)[C@H]1O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3N)O)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5N)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6N)O)O)CO)CO)CO)CO
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhao Q, et al. Chitoheptaose Promotes Heart Rehabilitation in a Rat Myocarditis Model by Improving Antioxidant, Anti-Inflammatory, and Antiapoptotic Properties. Oxid Med Cell Longev. 2020 Apr 11;2020:2394704. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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