2. Others Apoptosis Immunology/Inflammation
  3. Biochemical Assay Reagents Apoptosis Interleukin Related IFNAR
  4. Chitoheptaose

Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis.

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Chitoheptaose

Chitoheptaose Chemical Structure

CAS No. : 68232-35-9

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Chitoheptaose Related Antibodies

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Description

Chitoheptaose is an orally active chitooligosaccharide (degree of polymerization = 7). Chitoheptaose can be extracted from the exoskeletons of crustaceans, such as the shells of crabs, shrimps and lobsters. Chitoheptaose reduces pro-inflammatory cytokines while increasing the levels of anti-inflammatory cytokines (decreasing the levels of pro-inflammatory cytokines IL-1β, IL-17A and IFN-γ, and increasing the level of the anti-inflammatory cytokine IL-10). Chitoheptaose possesses antioxidant, anti-inflammatory and anti-Apoptotic activities. Chitoheptaose improves cardiac parameters, alleviates myocarditis injury, and exerts cardioprotective effects in a rat model of myocarditis. Chitoheptaose can be used in studies related to myocarditis[1].

IC50 & Target[1]

IL-1β

 

IL-17A

 

IL-10

 

In Vitro

Chitoheptaose (100 μM; 24 h prior to 6 h LPS stimulation at 200 ng/mL) exerts anti-inflammatory activity in LPS-stimulated RAW264.7 cells, with activity greater than chitopentaose and chitohexaose, ranking third among tested chitosan oligosaccharides with degree of polymerization >4[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chitoheptaose Related Antibodies

ELISA Assay[1]

Cell Line: RAW264.7 macrophage cells
Concentration: 100 μM
Incubation Time: 24 h (prior to 6 h LPS stimulation at 200 ng/mL)
Result: Reduced levels of proinflammatory cytokines IL-1β, IL-17A, and IFN-γ.
Increased levels of anti-inflammatory cytokine IL-10.
Showed significantly greater anti-inflammatory activity than chitopentaose and chitohexaose, but less than chitooctaose (p < 0.05).
In Vivo

Chitoheptaose (100 μM; p.o.; daily; 30 days) exerts superior cardioprotective effects in a rat autoimmune myocarditis model via enhanced antioxidant, anti-inflammatory, and antiapoptotic activities, improving cardiac function, reducing myocardial injury, and modulating inflammatory and apoptotic markers more effectively than other tested chitosan oligosaccharides (p < 0.05)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SPF rats (8-week-old, 200-220 g, experimental autoimmune myocarditis model induced by subcutaneous injection of porcine cardiac myosin emulsified with complete Freund’s adjuvant on day 1 and day 8)[1]
Dosage: 100 μM
Administration: p.o.; daily; 30 days
Result: Reduced left ventricular internal diameter in end diastole (LVIDd) and left ventricular internal diameter in end systole (LVIDs) significantly compared with other chitosan oligosaccharides (p < 0.05).
Increased ejection fraction (EF) and fractional shortening (FS) significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced myocardial histopathological scores and inflammatory cell infiltration more effectively than other chitosan oligosaccharides (p < 0.05).
Lowered serum levels of proinflammatory cytokines IL-1β, IL-17A, and IFN-γ, and increased anti-inflammatory cytokine IL-10 significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced cardiac tissue levels of reactive oxygen species (ROS) and reactive nitrogen species (RNS) significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced relative mRNA and protein levels of proapoptotic factors caspase 3 and BAX, and increased relative mRNA and protein levels of antiapoptotic factor BCL-2 significantly compared with other chitosan oligosaccharides (p < 0.05).
Reduced IHC scores for caspase 3 and BAX, and increased IHC scores for BCL-2 significantly compared with other chitosan oligosaccharides (p < 0.05).
Achieved a serum level of 45 μM after treatment.
Molecular Weight

1146.11

Formula

C42H79N7O29
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O[C@H]([C@@H]([C@H]1O)N)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2O)N)O[C@H]([C@H](O)CO)[C@H](O)[C@@H](N)C=O)CO)[C@H]1O[C@@H]3O[C@@H]([C@H]([C@@H]([C@H]3N)O)O[C@@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O[C@@H]5O[C@@H]([C@H]([C@@H]([C@H]5N)O)O[C@@H]6O[C@@H]([C@H]([C@@H]([C@H]6N)O)O)CO)CO)CO)CO
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Purity & Documentation

Purity: ≥98.0%

SDS (252 KB)

COA (260 KB)

Handling Instructions (2659 KB)
References
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Chitoheptaose Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Chitoheptaose68232-35-9Biochemical Assay ReagentsApoptosisInterleukin RelatedIFNARILInterferon-α/β receptorInterferon-alpha/beta receptorantiapoptotic factorreactive oxygen speciesrat autoimmune myocarditis modelchitosan oligosaccharideproapoptotic factorrat myocarditis modelanti-inflammatory cytokineproinflammatory cytokineRAW264.7 cellsreactive nitrogen speciesInhibitorinhibitorinhibit

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