IL-17-IN-6
IL-17-IN-6 is a IL-17 inhibitor with a pIC50 of 7.6 against human targets. IL-17-IN-6 binds to IL-17A and blocks downstream pro-inflammatory signaling pathways. IL-17-IN-6 inhibits the release of IL-6 from normal human skin fibroblasts stimulated by IL-17A and TNF. IL-17-IN-6 can be used for research on inflammatory and autoimmune diseases.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Fòrmula: C26H26F3N7O3
- Peso molecular:541.52
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Actividad biológica
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Chemical Information
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Help & FAQs
Actividad biológica
Descripciòn
IC50 & Target
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IL-17 7.6 (pIC50) |
In Vitro
IL-17-IN-6 (Compound 28) (up to 10 μM; pre-incubated for 30 min, followed by 24 h of cell incubation) potently inhibits IL-17A-mediated IL-6 production in normal human skin fibroblasts, with a cellular pIC50 value of 7.6[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Peso molecular 541.52
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Fòrmula C26H26F3N7O3
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SMILES
O=C(C1=CC=C(C=C1N(CC2=NNC([C@H](C3CCC(CC3)(F)F)NC(/C(F)=C\C4CC4)=O)=N2)C5=O)C#N)N5C
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IL-17-IN-6 Related Classifications
HY-181826 Related Classifications
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