12R-LOX-IN-2
Based on 1 Customer Validation
12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases.
For research use only. We do not sell to patients.
- Purity: 99.85%
- CAS No.: 3026677-37-9
- Formula: C19H13NO
- Molecular Weight:271.31
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
12R-lipoxygenase (12R-LOX)[1]
Chemical Information
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CAS No. 3026677-37-9
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Appearance Solid
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Molecular Weight 271.31
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Formula C19H13NO
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Color Off-white to yellow
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SMILES
OC(C1=C2C=CC=C1)=CC=C2C3=NC4=CC=CC=C4C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Solvent & Solubility
DMSO : 125 mg/mL (460.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (272 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6858 mL | 18.4291 mL | 36.8582 mL | 92.1455 mL |
| 5 mM | 0.7372 mL | 3.6858 mL | 7.3716 mL | 18.4291 mL | |
| 10 mM | 0.3686 mL | 1.8429 mL | 3.6858 mL | 9.2146 mL | |
| 15 mM | 0.2457 mL | 1.2286 mL | 2.4572 mL | 6.1430 mL | |
| 20 mM | 0.1843 mL | 0.9215 mL | 1.8429 mL | 4.6073 mL | |
| 25 mM | 0.1474 mL | 0.7372 mL | 1.4743 mL | 3.6858 mL | |
| 30 mM | 0.1229 mL | 0.6143 mL | 1.2286 mL | 3.0715 mL | |
| 40 mM | 0.0921 mL | 0.4607 mL | 0.9215 mL | 2.3036 mL | |
| 50 mM | 0.0737 mL | 0.3686 mL | 0.7372 mL | 1.8429 mL | |
| 60 mM | 0.0614 mL | 0.3072 mL | 0.6143 mL | 1.5358 mL | |
| 80 mM | 0.0461 mL | 0.2304 mL | 0.4607 mL | 1.1518 mL | |
| 100 mM | 0.0369 mL | 0.1843 mL | 0.3686 mL | 0.9215 mL |
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