3026677-37-9
Chemical Structure
12R-LOX-IN-2
- CAS No.: 3026677-37-9
- Formula:C19H13NO
- Molecular Weight:271.31
InChIKey: PLATVCRZPNTREE-UHFFFAOYSA-N
SMILES: OC(C1=C2C=CC=C1)=CC=C2C3=NC4=CC=CC=C4C=C3
Biological Activity: 12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases[1].
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12R-LOX-IN-2 | 99.85% | 12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases. | ||||||||||||||||||||
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Keywords
