Cat. No.: HY-N0902

Dihydrosanguinarine

(Synonyms: 13,14-Dihydrosanguinarine)

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Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis.

For research use only. We do not sell to patients.

Purity: 99.98%
CAS No.: 3606-45-9
Formula: C₂₀H₁₅NO₄
Molecular Weight:333.34

Storage:

Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year

Dihydrosanguinarine Chemical Structure

CAS No.: 3606-45-9

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Solvent & Solubility
- In Vitro
Purity & Documentation
References
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[2]

IL-6

IL-17A

All Interleukin Related Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	>30 μM Compound: 2; DHSA	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33479636]
NCI-H1975	IC₅₀	19.14 μM Compound: 2; DHSA	Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay Antiproliferative activity against human H1975 cells assessed as inhibition of cell growth incubated for 72 hrs by MTT assay	[PMID: 33479636]

In Vitro

Dihydrosanguinarine shows antibacterial activity against oral aerobic and anaerobic microorganisms with a minimum inhibitory concentration of 140-150 μg/mL^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dihydrosanguinarine (10-20 mg/kg) protects against LPS-triggered hepatitis in male BALB/c mice by reducing inflammatory pathology, modulating key cytokine levels, and regulating mRNA expression of inflammation-related genes^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3606-45-9
Appearance Solid
Molecular Weight 333.34
Formula C₂₀H₁₅NO₄
Color Off-white to light yellow
SMILES

CN1C2=C(C=C(OCO3)C3=C4)C4=CC=C2C5=CC=C6C(OCO6)=C5C1
Synonyms

13,14-Dihydrosanguinarine
Structure Classification
- Alkaloids
- Quinoline Alkaloids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (37.50 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.9999 mL

14.9997 mL

29.9994 mL

5 mM

0.6000 mL

2.9999 mL

5.9999 mL

10 mM

0.3000 mL

1.5000 mL

2.9999 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Dilution Calculator

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Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Hook ILI. Papaver bracteatum Lindley (Giant Scarlet Poppy): In Vitro Production of Benzophenanthridine Alkaloids. In: Bajaj YPS (eds). Medicinal and Aromatic Plants VII. Biotechnology in Agriculture and Forestry, vol 28. Springer, Berlin Heidelberg. 1994.

[2]. Yu HZ, et al. Botanical, quality control, phytochemistry, pharmacology and toxicology of Corydalis bungeana Turcz.: a review. TMRIM. 2023;7:e23016.

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.9999 mL	14.9997 mL	29.9994 mL	74.9985 mL
	5 mM	0.6000 mL	2.9999 mL	5.9999 mL	14.9997 mL
	10 mM	0.3000 mL	1.5000 mL	2.9999 mL	7.4999 mL
	15 mM	0.2000 mL	1.0000 mL	2.0000 mL	4.9999 mL
	20 mM	0.1500 mL	0.7500 mL	1.5000 mL	3.7499 mL
	25 mM	0.1200 mL	0.6000 mL	1.2000 mL	2.9999 mL
	30 mM	0.1000 mL	0.5000 mL	1.0000 mL	2.5000 mL

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Dihydrosanguinarine

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All Interleukin Related Isoforms

Biological Activity

Chemical Information

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

Dihydrosanguinarine Related Classifications

HY-N0902 Related Classifications