3606-45-9
Chemical Structure
Dihydrosanguinarine
Synonym(s): 13,14-Dihydrosanguinarine
- CAS No.: 3606-45-9
- Formula:C20H15NO4
- Molecular Weight:333.34
IUPAC Name: 13-methyl-13,14-dihydro-[1,3]dioxolo[4',5':4,5]benzo[1,2-c][1,3]dioxolo[4,5-i]phenanthridine
InChIKey: CIUHLXZTZWTVFL-UHFFFAOYSA-N
SMILES: CN1C2=C(C=C(OCO3)C3=C4)C4=CC=C2C5=CC=C6C(OCO6)=C5C1
Biological Activity: Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Dihydrosanguinarine | 99.98% | Dihydrosanguinarine (13,14-Dihydrosanguinarine) is an alkaloid with antibacterial and anti-inflammatory activities, and also an important precursor of Sanguinarine (HY-N0052). Dihydrosanguinarine targets and regulates the TNF/IL-17/PI3K signaling pathway, downregulates the levels of pro-inflammatory factors such as IL-17A, TNF-α and IL-6, upregulates the expression of TGF-β, inhibits myeloperoxidase activity, and regulates the transcription of multiple inflammation-related genes. Dihydrosanguinarine exhibits antibacterial activity against a variety of oral microorganisms. Dihydrosanguinarine can be used in research related to liver inflammation and oral flora dysbiosis. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
- [1]. Hook ILI. Papaver bracteatum Lindley (Giant Scarlet Poppy): In Vitro Production of Benzophenanthridine Alkaloids. In: Bajaj YPS (eds). Medicinal and Aromatic Plants VII. Biotechnology in Agriculture and Forestry, vol 28. Springer, Berlin Heidelberg. 1994.
- [2]. Yu HZ, et al. Botanical, quality control, phytochemistry, pharmacology and toxicology of Corydalis bungeana Turcz.: a review. TMRIM. 2023;7:e23016.
Keywords
