8-Hydroxydihydrochelerythrine
8-Hydroxydihydrochelerythrine is a benzophenanthridine alkaloid-derived, selective and competitive AChE inhibitor (IC50=0.61 μM) isolated from the roots of Zanthoxylum nitidum (Roxb.) DC. 8-Hydroxydihydrochelerythrine increases the content of acetylcholine in the synapses of cholinergic neurons and enhances cholinergic neurotransmission. 8-Hydroxydihydrochelerythrine is applicable to the research of neurodegenerative diseases with dementia such as Alzheimer's disease.
For research use only. We do not sell to patients.
- CAS No.: 4070-42-2
- Formula: C21H19NO5
- Molecular Weight:365.38
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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AChE 0.61 μM (IC50) |
BChE 34.6 μM (IC50) |
AChE 0.25 μM (Ki) |
Chemical Information
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CAS No. 4070-42-2
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Molecular Weight 365.38
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Formula C21H19NO5
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SMILES
OC1C2=C(C3=CC=C4C=C5OCOC5=CC4=C3N1C)C=CC(OC)=C2OC
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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