1. Metabolic Enzyme/Protease
  2. ROR
  3. RORγt Inverse agonist 6

RORγt Inverse agonist 6 

Cat. No.: HY-130243
Handling Instructions

RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the treatment of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo.

For research use only. We do not sell to patients.

RORγt Inverse agonist 6 Chemical Structure

RORγt Inverse agonist 6 Chemical Structure

CAS No. : 1887161-80-9

Size Stock
100 mg Get quote
250 mg Get quote
500 mg Get quote

* Please select Quantity before adding items.

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

RORγt Inverse agonist 6 (compound 43) is a RORγt inverse agonist for the treatment of Th17-driven autoimmune diseases. RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in vivo[1].

In Vivo

RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model[1].
RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng•h/mL at 1 mg/kg, po)[1].
RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose[1].

Animal Model: Mice[1].
Dosage: 30 mg/kg.
Administration: Orally twice: at 30 min before and 8 h after IL-23 administration.
Result: Inhibited the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose.
Molecular Weight

565.02

Formula

C₂₈H₂₉ClN₆O₅

CAS No.

1887161-80-9

SMILES

O=C([[email protected]]1CN(C(NC2=CC3=C(N(C(C)C)C(N(CC4CC4)C3=O)=O)C=C2)=O)CCO1)NC5=CC=C(C#N)C(Cl)=C5

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

RORγt Inverse agonist 6RORγt Inverse agonist6RORγt Inverse agonist-6RORRAR-related orphan receptorInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
RORγt Inverse agonist 6
Cat. No.:
HY-130243
Quantity:
MCE Japan Authorized Agent: