RORγt inverse agonist 13
Based on 1 publication(s) in Google Scholar
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved agent-like properties, with an IC50 of 63.8 nM.
For research use only. We do not sell to patients.
- Purity: 98.13%
- CAS No.: 2170477-75-3
- Formula: C23H17Cl2F3N2O4
- Molecular Weight:513.29
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Storage:Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) RORγt inverse agonist 13
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Customer Validation & Images
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Cell Imaging/Staining
Biological Activity
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ROR-γ 63.8 nM (IC50) |
RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3?μM in Th17 cell differentiation assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Imiquimod (IMQ)-induced psoriasis mice model[1].
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Dosage:25 mg/kg.
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Administration:Orally, twice daily.
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Result:Brought in a significant reduction in clinical severity of psoriasis as measured through the ear erythema, back skin erythema and scaliness scales.
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Animal Model:Male CD-1 Mice[1].
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Dosage:1 mg/kg (i.v.) and 5 mg/kg (p.o.)(Pharmacokinetic Analysis).
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Administration:IV or PO, single dose.
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Result:Cmax: 609.67 ng/mL (PO), 1550 ng/mL (IV).
T1/2: 3.63 h (PO), 3.04 h (IV).
Chemical Information
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CAS No. 2170477-75-3
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Appearance Solid
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Molecular Weight 513.29
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Formula C23H17Cl2F3N2O4
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Color White to off-white
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SMILES
O=C(O)CC1=CC=C(CNC(NC2=CC(Cl)=C(C3=CC=CC=C3OC(F)(F)F)C(Cl)=C2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Publications (1)
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Journal Impact Factor
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Most Recent
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Biochem Biophys Res Commun
High-throughput screening unveils AMG 837 and RORγt 13 as the potent Brucella inhibitor by targeting BacA. [Abstract]2025 Apr 9:757:151624. PMID: 40090117
RORγt inverse agonist 13 purchased from MedChemExpress. Usage Cited in: Biochem Biophys Res Commun. 2025 Apr 9:757:151624. [Abstract]
Ability of different concentrations compounds or drugs (GM, Gentamicin, Sterile; AMG 837; RORγt 13; RIF; 4, 16 μg/mL) to clear B. melitensis TZ in RAW264.7 cells at 24 h. Cells appear blue; B. melitensis TZ appear green.
Solvent & Solubility
DMSO : 100 mg/mL (194.82 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 1.9482 mL | 9.7411 mL | 19.4822 mL | 48.7054 mL |
| 5 mM | 0.3896 mL | 1.9482 mL | 3.8964 mL | 9.7411 mL | |
| 10 mM | 0.1948 mL | 0.9741 mL | 1.9482 mL | 4.8705 mL | |
| 15 mM | 0.1299 mL | 0.6494 mL | 1.2988 mL | 3.2470 mL | |
| 20 mM | 0.0974 mL | 0.4871 mL | 0.9741 mL | 2.4353 mL | |
| 25 mM | 0.0779 mL | 0.3896 mL | 0.7793 mL | 1.9482 mL | |
| 30 mM | 0.0649 mL | 0.3247 mL | 0.6494 mL | 1.6235 mL | |
| 40 mM | 0.0487 mL | 0.2435 mL | 0.4871 mL | 1.2176 mL | |
| 50 mM | 0.0390 mL | 0.1948 mL | 0.3896 mL | 0.9741 mL | |
| 60 mM | 0.0325 mL | 0.1624 mL | 0.3247 mL | 0.8118 mL | |
| 80 mM | 0.0244 mL | 0.1218 mL | 0.2435 mL | 0.6088 mL | |
| 100 mM | 0.0195 mL | 0.0974 mL | 0.1948 mL | 0.4871 mL |
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