1. Metabolic Enzyme/Protease
  2. ROR
  3. AZD-0284

AZD-0284 

Cat. No.: HY-120384
Handling Instructions

AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders.

For research use only. We do not sell to patients.

AZD-0284 Chemical Structure

AZD-0284 Chemical Structure

CAS No. : 2101291-07-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 519 In-stock
Estimated Time of Arrival: December 31
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 750 In-stock
Estimated Time of Arrival: December 31
50 mg USD 2250 In-stock
Estimated Time of Arrival: December 31
100 mg USD 3350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

AZD-0284 is an inverse agonist of the nuclear receptor RORγ. In development for the treatment of plaque psoriasis vulgaris and respiratory tract disorders[1].

IC50 & Target

RORγ[1]

Storage

4°C, stored under nitrogen

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (190.68 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9068 mL 9.5342 mL 19.0683 mL
5 mM 0.3814 mL 1.9068 mL 3.8137 mL
10 mM 0.1907 mL 0.9534 mL 1.9068 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 0.83 mg/mL (1.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 0.83 mg/mL (1.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 0.83 mg/mL (1.58 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Molecular Weight

524.43

Formula

C₂₁H₁₈F₆N₂O₅S

CAS No.

2101291-07-8

SMILES

O=C([[email protected]@H]1N(C(C)=O)CC2=C1C=CC(S(=O)(C)=O)=C2)NC3=CC=C(C(C(F)(F)F)(O)C(F)(F)F)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

Product Name:
AZD-0284
Cat. No.:
HY-120384
Quantity:

AZD-0284

Cat. No.: HY-120384