JNJ627
JNJ627 is a small molecule allosteric inhibitor of IL-17A with a KD of 92 nM. JNJ627 effectively inhibits the binding of IL-17A and IL-17RA, with an IC50 value of 16 nM. JNJ627 is capable of inhibiting the secretion of G-CSF (granulocyte colony-stimulating factor) caused by IL-17A stimulation. JNJ627 can be used for the study of autoimmune diseases (such as psoriasis).
For research use only. We do not sell to patients.
- Formula: C29H38N4O3S
- Molecular Weight:522.70
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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IL-17A |
Chemical Information
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Molecular Weight 522.70
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Formula C29H38N4O3S
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SMILES
CC1(SCCN[C@H]1C(NCC2=CC=CC(C(N[C@@H](C3CCCCC3)C(NC4=CC=CC=C4)=O)=O)=C2)=O)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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