2. Immunology/Inflammation
  3. Interleukin Related
  4. JNJ627

JNJ627 is a small molecule allosteric inhibitor of IL-17A with a KD of 92 nM. JNJ627 effectively inhibits the binding of IL-17A and IL-17RA, with an IC50 value of 16 nM. JNJ627 is capable of inhibiting the secretion of G-CSF (granulocyte colony-stimulating factor) caused by IL-17A stimulation. JNJ627 can be used for the study of autoimmune diseases (such as psoriasis).

For research use only. We do not sell to patients.

JNJ627

JNJ627 Chemical Structure

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JNJ627 Related Antibodies

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Description

JNJ627 is a small molecule allosteric inhibitor of IL-17A with a KD of 92 nM. JNJ627 effectively inhibits the binding of IL-17A and IL-17RA, with an IC50 value of 16 nM. JNJ627 is capable of inhibiting the secretion of G-CSF (granulocyte colony-stimulating factor) caused by IL-17A stimulation. JNJ627 can be used for the study of autoimmune diseases (such as psoriasis)[1].

IC50 & Target[1]

IL-17A

 

In Vitro

JNJ627 (0-2 h) abrogates IL-17A-induced G-CSF production from normal human keratinocytes with an apparent IC50 of 0.3 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JNJ627 Related Antibodies
Molecular Weight

522.70

Formula

C29H38N4O3S
SMILES

CC1(SCCN[C@H]1C(NCC2=CC=CC(C(N[C@@H](C3CCCCC3)C(NC4=CC=CC=C4)=O)=O)=C2)=O)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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JNJ627 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JNJ627JNJ 627JNJ-627Interleukin RelatedILAllosteric inhibitorDNA-encoded library (DEL)IL-17protein-protein interactionssmall moleculeInhibitorinhibitorinhibit

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